Microbiome: Focus on Causation and Mechanism

被引：176

作者：

Fischbach, Michael A. ^{[1
,2
,3
]}

机构：

[1] Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA

[2] Stanford Univ, ChEM H, Stanford, CA 94305 USA

[3] Chan Zuckerberg Biohub, Stanford, CA 94305 USA

来源：

CELL | 2018年 / 174卷 / 04期

关键词：

WIDE ASSOCIATION; GUT MICROBIOTA; COMMENSAL; HOST; INDIVIDUALS; ENGRAFTMENT; RESISTANCE; MODULATE; REVEALS; STRAINS;

D O I：

10.1016/j.cell.2018.07.038

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

There is tremendous enthusiasm for the microbiome in academia and industry. This Perspective argues that in order to realize its potential, the field needs to focus on establishing causation and molecular mechanism with an emphasis on phenotypes that are large in magnitude, easy to measure, and unambiguously driven by the microbiota.

引用

页码：785 / 790

页数：6

共 53 条

[1] Weight Gain After Fecal Microbiota Transplantation [J].

Alang, Neha ;

Kelly, Colleen R. .

OPEN FORUM INFECTIOUS DISEASES, 2015, 2 (01)

[2] Sphingolipids from a Symbiotic Microbe Regulate Homeostasis of Host Intestinal Natural Killer T Cells [J].

An, Dingding ;

Oh, Sungwhan F. ;

Olszak, Torsten ;

Neves, Joana F. ;

Avci, Fikri Y. ;

Erturk-Hasdemir, Deniz ;

Lu, Xi ;

Zeissig, Sebastian ;

Blumberg, Richard S. ;

Kasper, Dennis L. .

CELL, 2014, 156 (1-2) :123-133

[3] Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota [J].

Atarashi, Koji ;

Tanoue, Takeshi ;

Oshima, Kenshiro ;

Suda, Wataru ;

Nagano, Yuji ;

Nishikawa, Hiroyoshi ;

Fukuda, Shinji ;

Saito, Takuro ;

Narushima, Seiko ;

Hase, Koji ;

Kim, Sangwan ;

Fritz, Joelle V. ;

Wilmes, Paul ;

Ueha, Satoshi ;

Matsushima, Kouji ;

Ohno, Hiroshi ;

Olle, Bernat ;

Sakaguchi, Shimon ;

Taniguchi, Tadatsugu ;

Morita, Hidetoshi ;

Hattori, Masahira ;

Honda, Kenya .

NATURE, 2013, 500 (7461) :232-+

[4] Functional overlap of the Arabidopsis leaf and root microbiota [J].

Bai, Yang ;

Mueller, Daniel B. ;

Srinivas, Girish ;

Garrido-Oter, Ruben ;

Potthoff, Eva ;

Rott, Matthias ;

Dombrowski, Nina ;

Muench, Philipp C. ;

Spaepen, Stijn ;

Remus-Emsermann, Mitja ;

Huettel, Bruno ;

McHardy, Alice C. ;

Vorholt, Julia A. ;

Schulze-Lefert, Paul .

NATURE, 2015, 528 (7582) :364-+

[5] Is brain estradiol a hormone or a neurotransmitter? [J].

Balthazart, Jacques ;

Ball, Gregory F. .

TRENDS IN NEUROSCIENCES, 2006, 29 (05) :241-249

[6] The Human Urine Metabolome [J].

Bouatra, Souhaila ;

Aziat, Farid ;

Mandal, Rupasri ;

Guo, An Chi ;

Wilson, Michael R. ;

Knox, Craig ;

Bjorndahl, Trent C. ;

Krishnamurthy, Ramanarayan ;

Saleem, Fozia ;

Liu, Philip ;

Dame, Zerihun T. ;

Poelzer, Jenna ;

Huynh, Jessica ;

Yallou, Faizath S. ;

Psychogios, Nick ;

Dong, Edison ;

Bogumil, Ralf ;

Roehring, Cornelia ;

Wishart, David S. .

PLOS ONE, 2013, 8 (09)

[7] Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve [J].

Bravo, Javier A. ;

Forsythe, Paul ;

Chew, Marianne V. ;

Escaravage, Emily ;

Savignac, Helene M. ;

Dinan, Timothy G. ;

Bienenstock, John ;

Cryan, John F. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (38) :16050-16055

[8] Culturing of 'unculturable' human microbiota reveals novel taxa and extensive sporulation [J].

Browne, Hilary P. ;

Forster, Samuel C. ;

Anonye, Blessing O. ;

Kumar, Nitin ;

Neville, B. Anne ;

Stares, Mark D. ;

Goulding, David ;

Lawley, Trevor D. .

NATURE, 2016, 533 (7604) :543-+

[9] Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile [J].

Buffie, Charlie G. ;

Bucci, Vanni ;

Stein, Richard R. ;

McKenney, Peter T. ;

Ling, Lilan ;

Gobourne, Asia ;

No, Daniel ;

Liu, Hui ;

Kinnebrew, Melissa ;

Viale, Agnes ;

Littmann, Eric ;

van den Brink, Marcel R. M. ;

Jenq, Robert R. ;

Taur, Ying ;

Sander, Chris ;

Cross, Justin R. ;

Toussaint, Nora C. ;

Xavier, Joao B. ;

Pamer, Eric G. .

NATURE, 2015, 517 (7533) :205-U207

[10] Microbial Reconstitution Reverses Maternal Diet-Induced Social and Synaptic Deficits in Offspring [J].

Buffington, Shelly A. ;

Di Prisco, Gonzalo Viana ;

Auchtung, Thomas A. ;

Ajami, Nadim J. ;

Petrosino, Joseph F. ;

Costa-Mattioli, Mauro .

CELL, 2016, 165 (07) :1762-1775

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