Chromosome abnormalities additional to the Philadelphia chromosome at the diagnosis of chronic myelogenous leukemia: pathogenetic and prognostic implications

被引：21

作者：

Zaccaria, Alfonso ^{[1
]}

Testoni, Nicoletta ^{[2
]}

Valenti, Anna Maria ^{[3
]}

Luatti, Simona ^{[2
]}

Tonelli, Michela ^{[3
]}

Marzocchi, Giulia ^{[2
]}

Cipriani, Raffaella ^{[1
]}

Baldazzi, Carmen ^{[2
]}

Giannini, Barbara ^{[3
]}

Stacchini, Monica ^{[2
]}

Gamberini, Carla ^{[2
]}

Castagnetti, Fausto ^{[2
]}

Rosti, Gianantonio ^{[2
]}

Azzena, Annalisa ^{[4
]}

Cavazzini, Francesco ^{[5
]}

Cianciulli, Anna Maria ^{[6
]}

Dalsass, Alessia ^{[7
]}

Donti, Emilio ^{[8
]}

Giugliano, Emilia ^{[9
]}

Gozzetti, Alessandro ^{[10
]}

Grimoldi, Maria Grazia ^{[11
]}

Ronconi, Sonia ^{[12
]}

Santoro, Alessandra ^{[13
]}

Spedicato, Francesco ^{[14
]}

Zanatta, Lucia ^{[15
]}

Baccarani, Michele ^{[2
]}

机构：

[1] S Maria delle Croci Hosp, Dept Hematol Oncol, I-48121 Ravenna, Italy

[2] Univ Bologna, Dept Hematol & Oncol L e A Seragnoli, I-40138 Bologna, Italy

[3] S Maria delle Croci Hosp, Dept Pathol, I-48121 Ravenna, Italy

[4] Binaghi Hosp, I-09126 Cagliari, Italy

[5] Arcispedale St Anna, Cytogenet Lab, Hematol Sect, I-44100 Ferrara, Italy

[6] Regina Elena Inst Canc Res, Dept Clin Pathol, SSO Cytogenet, I-00128 Rome, Italy

[7] Mazzoni Hosp, Citogenet Lab, I-63100 Ascoli Piceno, Italy

[8] Univ Perugia, Prenatal Diag Gen Exp Med Dept, I-06128 Perugia, Italy

[9] Univ Turin, I-10126 Turin, Italy

[10] Univ Siena, Chair Hematol, Div Hematol & Transplants, I-53100 Siena, Italy

[11] Univ Milan, Cytogenet Unit, I-20142 Milan, Italy

[12] IRST, Hematol Sect, I-47014 Meldola, Forli, Italy

[13] V Cervello Hosp, Hematol Lab, Clin Res & Biotechnol Dept, I-90146 Palermo, Italy

[14] SS Annunziata Hosp, Med Genet Lab, I-74100 Taranto, Italy

[15] Ca Foncello Hosp, Dept Pathol, Cytogenet Lab, I-31100 Treviso, Italy

来源：

CANCER GENETICS AND CYTOGENETICS | 2010年 / 199卷 / 02期

关键词：

CHRONIC MYELOID-LEUKEMIA; IMATINIB MESYLATE; CYTOGENETIC ABNORMALITIES; INTERFERON-ALPHA; PH; THERAPY; RESISTANCE; MECHANISMS; EMERGENCE; PATIENT;

D O I：

10.1016/j.cancergencyto.2010.02.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Additional chromosome abnormalities (ACAs) occur in less than 10% of cases at diagnosis of Philadelphia chromosome (Ph)-positive chronic myelogenous leukemia (CML). In some cases, on the basis of the persistence of the ACAs in Ph-negative cells after response to imatinib, a secondary origin of the Ph chromosome has been demonstrated. In this study, the possible prognostic value of this phenomenon was evaluated. Thirty-six Ph-positive CML patients were included in the study. In six patients, ACAs persisted after the disappearance of the Ph. A complete cytogenetic response (CCR) was obtained in five of these six patients, and five of six also had a high Sokal score. In all the other cases, ACAs disappeared together (in cases of response to therapy with imatinib) or persisted with the Ph (in cases of no response to imatinib). In the former cases, the primary origin of the Ph was demonstrated. CCR was obtained in 22 cases (17 with low to intermediate Sokal scores), while no response was observed in 8 patients (5 with a high Sokal score). Sokal score seems to maintain its prognostic value for patients in whom the Ph occurs as a primary event, but not in those in whom it occurs as a secondary one. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：76 / 80

页数：5

共 21 条

[21] Persistence of chromosomal abnormalities additional to the Philadelphia chromosome after Philadelphia chromosome disappearance during imatinib therapy for chronic myeloid leukemia
Zaccaria, Alfonso
Valenti, Anna Maria
Donti, Emilio
Gozzetti, Alessandro
Ronconi, Sonia
Spedicato, Francesco
[J]. HAEMATOLOGICA, 2007, 92 (04) : 564 - 565

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