Effects of chronic bryostatin-1 on treatment-resistant depression in rats

被引：9

作者：

Alkon, Daniel L. ^{[2
]}

Hongpaisan, Jarin ^{[1
]}

Sun, Miao-Kun ^{[1
]}

机构：

[1] Blanchette Rockefeller Neurosci Inst, 8 Med Ctr Dr, Morgantown, WV 26505 USA

[2] NeuroDiagnost LLC, Rockville, MD USA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2017年 / 807卷

关键词：

Bryostatin; 1; Depression; Refractory depression; Spatial learning and memory; ANTIDEPRESSANT ACTIVITY; CLINICAL-PRACTICE; MAJOR DEPRESSION; ANIMAL-MODELS; MEMORY; THERAPEUTICS; DISORDERS; BEHAVIOR; KETAMINE; TRIALS;

D O I：

10.1016/j.ejphar.2017.05.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Despite over a half-century's intensive research worldwide, the currently available antidepressants remain suboptimal. Therapeutic options for treatment-resistant depression, for instance, are rather limited. Here, we found that rats exhibited a lasting treatment-resistant depressive immobility in response to open space swim test at a high intensity of induction. The induced depressive behavior is associated with a dramatic impairment in spatial learning and memory. Both the depressive immobility and impairment in spatial learning and memory are sensitive to a period of chronic treatment with bryopstatin-1, a relatively selective activator of protein kinase C epsilon. Bryostatin-1-like analogues therefore might have therapeutic values for the treatment of treatment-resistant depression.

引用

页码：71 / 74

页数：4

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