Ischemic Stroke and SARS-CoV-2 Infection: The Bidirectional Pathology and Risk Morbidities

被引：36

作者：

Chavda, Vishal ^{[1
]}

Chaurasia, Bipin ^{[2
]}

Fiorindi, Alessandro ^{[3
]}

Umana, Giuseppe E. ^{[4
]}

Lu, Bingwei ^{[1
]}

Montemurro, Nicola ^{[5
]}

机构：

[1] Stanford Univ, Stanford Sch Med, Med Ctr, Dept Pathol, San Francisco, CA 94305 USA

[2] Bhawani Hosp & Res Ctr, Dept Neurosurg, Birgunj 44300, Nepal

[3] Univ Brescia, SpedaliCivili, Dept Med & Surg Specialties Radiol Sci & Publ Hlt, Neurosurg, I-25100 Brescia, Italy

[4] Cannizzaro Hosp, Trauma & Gamma Knife Ctr, Dept Neurosurg, I-95100 Catania, Italy

[5] Univ Pisa, Azienda Osped Univ Pisana AOUP, Dept Neurosurg, I-56100 Pisa, Italy

来源：

NEUROLOGY INTERNATIONAL | 2022年 / 14卷 / 02期

关键词：

COVID-19; anti-coagulants; ischemia; SARS-CoV-2; therapeutics; neurology; neurosurgery; stroke; COVID-19; COMPLICATIONS; CORONAVIRUS; PATIENT; MITOCHONDRIA; DYSFUNCTION; HEMORRHAGE;

D O I：

10.3390/neurolint14020032

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Stroke is a fatal morbidity that needs emergency medical admission and immediate medical attention. COVID-19 ischemic brain damage is closely associated with common neurological symptoms, which are extremely difficult to treat medically, and risk factors. We performed literature research about COVID-19 and ischemia in PubMed, MEDLINE, and Scopus for this current narrative review. We discovered parallel manifestations of SARS-CoV-19 infection and brain ischemia risk factors. In published papers, we discovered a similar but complex pathophysiology of SARS-CoV-2 infection and stroke pathology. A patient with other systemic co-morbidities, such as diabetes, hypertension, or any respiratory disease, has a fatal combination in intensive care management when infected with SARS-CoV-19. Furthermore, due to their shared risk factors, COVID-19 and stroke are a lethal combination for medical management to treat. In this review, we discuss shared pathophysiology, adjuvant risk factors, challenges, and advancements in stroke-associated COVID-19 therapeutics.

引用

页码：391 / 405

页数：15

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