Maternal and early life exposure to phthalates: The Plastics and Personal-care Products use in Pregnancy (P4) study

被引:61
作者
Arbuckle, Tye E. [1 ]
Fisher, Mandy [1 ]
MacPherson, Susan [1 ]
Lang, Carly [1 ]
Provencher, Gilles [2 ]
LeBlanc, Alain [2 ]
Hauser, Russ [3 ]
Feeley, Mark [4 ]
Ayotte, Pierre [2 ,5 ]
Neisa, Angelica [1 ]
Ramsay, Tim [6 ,7 ]
Tawagi, George [8 ]
机构
[1] Hlth Canada, Populat Studies Div, Hlth Environm & Consumer Safety Branch, 50 Colombine Dr,AL 0801A, Ottawa, ON K1A 0K9, Canada
[2] INSPQ, CTQ, Quebec City, PQ, Canada
[3] Harvard Univ, Sch Publ Hlth, Dept Environm Hlth & Epidemiol, 665 Huntington Ave, Boston, MA 02115 USA
[4] Hlth Canada, Hlth Prod & Food Branch, Bur Chem Safety, Ottawa, ON K1A 0L2, Canada
[5] CHU Quebec, Ctr Rech, Axe Sante Populat & Prat Optimales Sante, Quebec City, PQ, Canada
[6] Ottawa Hosp, Res Inst, Clin Epidemiol Program, Ottawa, ON, Canada
[7] Univ Ottawa, Dept Obstet & Gynecol, Ottawa, ON, Canada
[8] Ottawa Hosp, Dept Obstet & Perinatal Med, Ottawa, ON, Canada
关键词
Metabolites; Urine; Meconium; Infant; Pregnancy; Breast milk; 1ST TRIMESTER PHTHALATE; SOLID-PHASE EXTRACTION; BISPHENOL-A EXPOSURE; URINARY CONCENTRATIONS; BREAST-MILK; DI(2-ETHYLHEXYL) PHTHALATE; METABOLITE CONCENTRATIONS; ENDOCRINE DISRUPTORS; DIETHYL PHTHALATE; PRENATAL EXPOSURE;
D O I
10.1016/j.scitotenv.2016.02.022
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Phthalates are a group of chemicals found in a number of consumer products; some of these phthalates have been shown to possess estrogenic activity and display anti-androgenic effects. While a number of biomonitoring studies of phthalates in pregnant women and infants have been published, there is a paucity of data based on both multiple sampling periods and in different matrices. Phthalate metabolites were measured in 80 pregnant women and their infants in Ottawa Canada (2009-2010) in urine, meconium and breast milk collected at various time periods pre- and post-parturition. At least 50% of the women had at least one urine sample greater than the limit of detection (LOD) for the various phthalate metabolites, with the exception of mono-n-octyl phthalate MnOP), mono-isononyl phthalate (MiNP) and mono(carboxy-isooctyl) phthalate (MCiOP). Four major clusters of maternal urinary metabolites were identified. Among infants (n = 61), the following metabolites were rarely (< 10%) detected: mono-cyclohexyl phthalate (MCHP), mono-isononyl phthalate (MiNP), mono-methyl phthalate (MMP), and mono-n-octyl phthalate (MnOP). While mono-benzyl phthalate (MBzP), mono-3-carboxypropyl phthalate (MCPP), MEHHP, and MEOHP were frequently detected in maternal urines at any time point, these metabolites were rarely detected in breast milk. Maternal urinary concentrations of MEP and the DEHP metabolites were higher in samples collected during pregnancy than postnatally. No statistically significant differences were observed in infant's urinary phthalate concentrations between breast-fed and bottle-fed infants. Significant correlations were observed between maternal urinary MEHHP (r = 0.35), MEOHP (r = 0.35) and MEP (r = 0.37) collected at <20 weeks gestation with levels in meconium and between MBzP (r = 0.78) and MEP (r = 0.56) in maternal and infant urine collected 2-3 months after birth. These results suggest at least some maternal-fetal-infant transfer of phthalates and that meconium may be a useful matrix for measuring in utero exposure to phthalates. Crown Copyright (C) 2016 Published by Elsevier B.V.
引用
收藏
页码:344 / 356
页数:13
相关论文
共 90 条
[21]   Prenatal phthalate exposure and performance on the Neonatal Behavioral Assessment Scale in a multiethnic birth cohort [J].
Engel, Stephanie M. ;
Zhu, Chenbo ;
Berkowitz, Gertrud S. ;
Calafat, Antonia M. ;
Silva, Manori J. ;
Miodovnik, Amir ;
Wolff, Mary S. .
NEUROTOXICOLOGY, 2009, 30 (04) :522-528
[22]   Phthalate exposure in pregnant women and newborns - The urinary metabolite excretion pattern differs distinctly [J].
Enke, Uta ;
Schleussner, Ekkehard ;
Paelmke, Claudia ;
Seyfarth, Lydia ;
Koch, Holger Martin .
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH, 2013, 216 (06) :735-742
[23]   Persistent Associations between Maternal Prenatal Exposure to Phthalates on Child IQ at Age 7 Years [J].
Factor-Litvak, Pam ;
Insel, Beverly ;
Calafat, Antonia M. ;
Liu, Xinhua ;
Perera, Frederica ;
Rauh, Virginia A. ;
Whyatt, Robin M. .
PLOS ONE, 2014, 9 (12)
[24]   Variability in urinary phthalate metabolite levels across pregnancy and sensitive windows of exposure for the risk of preterm birth [J].
Ferguson, Kelly K. ;
McElrath, Thomas F. ;
Ko, Yi-An ;
Mukherjee, Bhramar ;
Meeker, John D. .
ENVIRONMENT INTERNATIONAL, 2014, 70 :118-124
[25]   Environmental Phthalate Exposure and Preterm Birth [J].
Ferguson, Kelly K. ;
McElrath, Thomas F. ;
Meeker, John D. .
JAMA PEDIATRICS, 2014, 168 (01) :61-67
[26]   Bisphenol A and phthalate metabolite urinary concentrations: Daily and across pregnancy variability [J].
Fisher, Mandy ;
Arbuckle, Tye E. ;
Mallick, Ranjeeta ;
LeBlanc, Alain ;
Hauser, Russ ;
Feeley, Mark ;
Koniecki, Diane ;
Ramsay, Tim ;
Provencher, Gilles ;
Berube, Rene ;
Walker, Mark .
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY, 2015, 25 (03) :231-239
[27]   Metabolism of phthalates in humans [J].
Frederiksen, Hanne ;
Skakkebaek, Niels E. ;
Andersson, Anna-Maria .
MOLECULAR NUTRITION & FOOD RESEARCH, 2007, 51 (07) :899-911
[28]   A Longitudinal Study of Urinary Phthalate Excretion in 58 Full-Term and 67 Preterm Infants from Birth through 14 Months [J].
Frederiksen, Hanne ;
Kuiri-Hanninen, Tanja ;
Main, Katharina M. ;
Dunkel, Leo ;
Sankilampi, Ulla .
ENVIRONMENTAL HEALTH PERSPECTIVES, 2014, 122 (09) :998-1005
[29]   Phthalates in German daycare centers: Occurrence in air and dust and the excretion of their metabolites by children (LUPE 3) [J].
Fromme, H. ;
Lahrz, T. ;
Kraft, M. ;
Fembacher, L. ;
Dietrich, S. ;
Sievering, S. ;
Burghardt, R. ;
Schuster, R. ;
Bolte, G. ;
Voelkel, W. .
ENVIRONMENT INTERNATIONAL, 2013, 61 :64-72
[30]   Phthalates and their metabolites in breast milk - Results from the Bavarian Monitoring of Breast Milk (BAMBI) [J].
Fromme, H. ;
Gruber, L. ;
Seckin, E. ;
Raab, U. ;
Zimmermann, S. ;
Kiranoglu, M. ;
Schlummer, M. ;
Schwegler, U. ;
Smolic, S. ;
Voelkel, W. .
ENVIRONMENT INTERNATIONAL, 2011, 37 (04) :715-722