Pharmacological targeting of TNS3 with histone deacetylase inhibitor as a therapeutic strategy in esophageal squamous cell carcinoma

被引：5
作者：
Shi, Yang [1 ,2 ]
Xiang, Zheng [4 ]
Yang, Huiyu [1 ,2 ]
Khan, Suliman [5 ]
Li, Ruizhe [3 ]
Zhou, Siran [1 ,2 ]
Ullah, Saif [1 ,2 ]
Zhang, Jiyu [1 ,2 ]
Liu, Bingrong [1 ,2 ]
机构：
[1] Zhengzhou Univ, Dept Gastroenterol, Affiliated Hosp 1, Zhengzhou 450052, Peoples R China
[2] Zhengzhou Univ, State Key Lab Esophageal Canc Prevent & Treatment, Zhengzhou 450052, Peoples R China
[3] Zhengzhou Univ, Affiliated Hosp 1, Dept Pathol, Zhengzhou 450052, Peoples R China
[4] Zhengzhou Univ, Henan Univ, Henan Prov Peoples Hosp, Dept Pathol,Peoples Hosp, Zhengzhou 450003, Peoples R China
[5] Zhengzhou Univ, Affiliated Hosp 2, Dept Cerebrovasc Dis, Zhengzhou 450000, Peoples R China
来源：
AGING-US | 2021年 / 13卷 / 11期
基金：
中国国家自然科学基金;
关键词：
histone deacetylase inhibitors; LMK-235; esophageal squamous cell carcinoma; tensin-3; histone acetylation; SRC FAMILY KINASES; HDAC INHIBITORS; PROTEIN; EPIGENETICS; COMBINATION; EXPRESSION; PACKAGE;
D O I：
10.18632/aging.203091
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Histone acetylation which regulates about 2-10% of genes has been demonstrated to be involved in tumorigenesis of esophageal squamous cell carcinoma (ESCC). In this study, we investigated the treatment response of ESCC to selective histone deacetylase inhibitor (HDACi) LMK-235 and potential biomarker predicting the treatment sensitivity. We identified tensin-3 (TNS3) which was highly over-expressed in ESCC as one of the down-regulated genes in response to LMK-235 treatment. TNS3 was found positively correlated with the tumor malignancy and poor prognosis in the patients. Silencing TNS3 significantly inhibited ESCC cell proliferation both in vitro and in vivo, sensitizing the treatment response to LMK-235. Our findings provide an insight into understanding the oncogenic role of TNS3 in ESCC and its clinical application for HDAC targeted therapy of ESCC.
引用
收藏
页码：15336 / 15352
页数：17
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