Synthesis and antibacterial activity of new 4-alkoxy, 4-aminoalkyl and 4-alkylthioquinoline derivatives

被引：45
作者：
Kayirere, MG
Mahamoud, A
Chevalier, J
Soyfer, JC
Crémieux, A
Barbe, J
机构：
[1] Fac Pharm Marseille, GERCTOP, CNRS, UPRESA 6009, F-13385 Marseille 5, France
[2] Fac Pharm Marseille, MICRAAM, AFCOPAT, F-13385 Marseille, France
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1998年 / 33卷 / 01期
关键词：
quinolines; antibacterial agents; structure-activity relationship;
D O I：
10.1016/S0223-5234(99)80076-2
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
4-Alkoxy-8-methyl-7-nitroquinolines, 4-alkylamino-8-methyl-7-nitroquinolines, 4-alkoxy-2,8-dimethylquinolines, 4-alkylthioquinolines were prepared from 8-methyl-7-nitro-4-quinolone, 8-methyl-7-nitro-4-chloro-quinoline, 2,8-dimethyl-4-quinolone and 4-hydroxyquinoline used as starting material. Compounds were characterized from H-1 and C-13 NMR spectra. These drugs were tested against selected gram-, gram+ and mycobacteria strains. A promising activity was observed against Mycobacterium smegmatis. (C) Elsevier, Paris.
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页码：55 / 63
页数：9
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