Soluble adhesion molecules in type 1 diabetes mellitus

被引：13

作者：

Martin, S ^{[1
]}

机构：

[1] Univ Dusseldorf, Diabet Res Inst, D-40225 Dusseldorf, Germany

来源：

HORMONE AND METABOLIC RESEARCH | 1997年 / 29卷 / 12期

关键词：

soluble ICAM-1; IDDM; chronic inflammation;

D O I：

10.1055/s-2007-979117

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Adhesion molecules play an important role during leukocyte emgration from blood vessels. Furthermore, adhesion molecules are involved in the regulation of the immune system, In addition to membrane-bound adhesion molecules soluble forms have been detected in human serum. During the last few years we have analysed the role of adhesion molecules during the pathogenesis of type I diabetes. This review describes the results of studies on membrane-bound and soluble adhesion molecules in humans and the model of the NOD mouse. Based on these results different adhesion molecule-specific immunotherapies are presented for the prevention of type 1 diabetes and its preclinical stages.

引用

页码：639 / 642

页数：4

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