Hydroxypropyl methylcellulose (HPMC) formulated films: Relevance to adhesion and friction surface properties

被引：61

作者：

Fahs, Ahmad ^{[1
]}

Brogly, Maurice ^{[1
]}

Bistac, Sophie ^{[1
]}

Schmitt, Marjorie ^{[1
]}

机构：

[1] Ecole Natl Super Chim, Lab Chim Organ Bioorgan & Macromol, F-68093 Mulhouse, France

来源：

CARBOHYDRATE POLYMERS | 2010年 / 80卷 / 01期

关键词：

Hydroxypropyl methylcellulose; Stearic acid; Adhesion; Friction; Atomic force microscopy; Nanoscale/macroscale; SELF-ASSEMBLED MONOLAYERS; ATOMIC-FORCE MICROSCOPE; EDIBLE FILMS; FATTY-ACID; BARRIER PROPERTIES; FREE-ENERGY; HYDROXYPROPYLMETHYLCELLULOSE; CELLULOSE; INTERFACE; TABLETS;

D O I：

10.1016/j.carbpol.2009.10.071

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Cellulose derivatives constitute one of the most dedicated polymers used in the production of film coatings (tablets, capsules ...). The effect of the composition of hydroxypropyl methylcellulose (HPMC)-stearic acid films on the surface physico-chemical properties was investigated. Incorporation of stearic acid into HPMC films induces strong changes on surface structure, hydrophobic/hydrophilic character, adhesion and friction characteristics. The variations observed suggest an accumulation of stearic acid on film surfaces, resulting a decrease of its roughness and surface free energy. The nano-adhesion and nano-friction experiments were evaluated by using AFM/FFM, while the macro-adhesion and macro tribological Studies were performed on tack test and pin-on-disk tribometer respectively. In all the cases, it was found that the hydrophobic character of stearic acid leads to decrease adhesion and friction at the two scales. The surface capillary force plays a key role in these properties. In addition, the Study indicates the interplay of adhesion in friction property of HPMC films and the role of stearic acid as lubricant. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：105 / 114

页数：10

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