Corynebacterium diphtheriae Infection in Mahajanga, Madagascar: First Case Report

被引：3

作者：

Rakotomalala, Rivo Solotiana ^{[1
]}

Andrianirina, Zo Zafitsara ^{[2
]}

Ratsima, Elisoa ^{[3
]}

Randrianandraina, Patrick ^{[4
]}

Randrianirina, Frederique ^{[3
]}

Edosoa, Glenn Torrencelli ^{[5
]}

Rabenandrianina, Tahirimalala ^{[1
]}

Badell, Edgar ^{[6
,7
]}

Toubiana, Julie ^{[6
,7
,8
]}

Andrianarimanana, Diavolana ^{[2
]}

Brisse, Sylvain ^{[6
,7
]}

Rasamindrakotroka, Andry ^{[9
]}

机构：

[1] Univ Mahajanga, Ctr Hosp Univ PZAGA, Dept Sci Fondamentales, Lab Biol Med, Mahajanga 401, Madagascar

[2] Univ Mahajanga, Ctr Hosp Univ PZAGA, Dept Pediat, Mahajanga 401, Madagascar

[3] Inst Pasteur Madagascar, Ctr Biol Clin, Antananarivo 101, Madagascar

[4] Univ Mahajanga, Ctr Hosp Univ PZAGA, Serv ORL, Mahajanga 401, Madagascar

[5] Bur Pays Madagascar, Org Mondiale Sante, Antananarivo 101, Madagascar

[6] Natl Reference Ctr Corynebacteria Diphtheriae Com, Inst Pasteur, F-75015 Paris, France

[7] Inst Pasteur Biodivers & Epidemiol Bacterial Path, F-75015 Paris, France

[8] Univ Paris, Necker Enfants Malad, AP HP, Gen Pediat & Pediat Infect Dis Dept, F-75015 Paris, France

[9] Univ Antananar, Fac Med, Lab Format & Rech Biol Med, Antananarivo 101, Madagascar

来源：

JOURNAL OF TROPICAL PEDIATRICS | 2021年 / 67卷 / 01期

关键词：

Corynebacterium diphtheriae; diphtheria toxin; pharyngitis;

D O I：

10.1093/tropej/fmaa064

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Diphtheria is an infection that has been unreported for more than two decades in Mahajanga. A child, aged 4, presented with a pseudomembranous pharyngitis was associated with a dysphagia. He was from a rural municipality of Ambato Boeny at Mahajanga province and was admitted to the Pediatric Unit of the University Hospital Center. The child was not immunized against diphtheria. A throat swab was performed and cultured, from which Corynebacterium diphtheriae was identified. The strain, of biovar Mitis, was confirmed as diphtheria toxin (DT)-gene positive and produced DT (Elek test). Unfortunately, the child developed cardiac and neurological complications and died of respiratory and heart failure.

引用

页数：4

共 26 条

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