Multilayered Polyelectrolyte Microcapsules: Interaction with the Enzyme Cytochrome C Oxidase

被引：6

作者：

Pastorino, Laura ^{[1
]}

Dellacasa, Elena ^{[1
]}

Noor, Mohamed R. ^{[2
,5
]}

Soulimane, Tewfik ^{[2
,5
]}

Bianchini, Paolo ^{[3
]}

D'Autilia, Francesca ^{[3
]}

Antipov, Alexei ^{[4
]}

Diaspro, Alberto ^{[3
]}

Tofail, Syed A. M. ^{[5
]}

Ruggiero, Carmelina ^{[1
]}

机构：

[1] Univ Genoa, Dept Informat Bioengn Robot & Syst Engn, Genoa, Italy

[2] Univ Limerick, Dept Chem & Environm Sci, Limerick, Ireland

[3] Ist Italiano Tecnol, Genoa, Italy

[4] PlasmaChem GmbH, Berlin, Germany

[5] Univ Limerick, Mat & Surface Sci Inst, Limerick, Ireland

来源：

PLOS ONE | 2014年 / 9卷 / 11期

关键词：

THERMUS-THERMOPHILUS; POLYMERIC CAPSULES; FILMS; ENCAPSULATION; STABILITY; NEUTRON; DENSITY;

D O I：

10.1371/journal.pone.0112192

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cell-sized polyelectrolyte capsules functionalized with a redox-driven proton pump protein were assembled for the first time. The interaction of polyelectrolyte microcapsules, fabricated by electrostatic layer-by-layer assembly, with cytochrome c oxidase molecules was investigated. We found that the cytochrome c oxidase retained its functionality, that the functionalized microcapsules interacting with cytochrome c oxidase were permeable and that the permeability characteristics of the microcapsule shell depend on the shell components. This work provides a significant input towards the fabrication of an integrated device made of biological components and based on specific biomolecular functions and properties.

引用

页数：7

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