Artificial intelligence and guidance of medicine in the bubble

被引：15

作者：

Akbar, Asma ^{[1
]}

Pillalamarri, Nagavalli ^{[1
]}

Jonnakuti, Sriya ^{[1
]}

Ullah, Mujib ^{[1
,2
]}

机构：

[1] Stanford Univ, Sch Med, Inst Immun & Transplantat Stem Cell Biol & Regene, Palo Alto, CA 94304 USA

[2] Stanford Univ, Sch Med, Dept Biomed Innovat & Bioengn, Mol Med, Palo Alto, CA 94304 USA

来源：

CELL AND BIOSCIENCE | 2021年 / 11卷 / 01期

关键词：

Artificial intelligence; Microbubbles; Nano-vesicles; Drug transportation; Targeted therapies; BLOOD-BRAIN-BARRIER; ON-CHIP GENERATION; FOCUSED ULTRASOUND; DRUG-DELIVERY; EXTRACELLULAR VESICLES; CLINICAL-APPLICATIONS; PRECISION MEDICINE; OXYGEN DELIVERY; CONTRAST AGENTS; MICROBUBBLES;

D O I：

10.1186/s13578-021-00623-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Microbubbles are nanosized gas-filled bubbles. They are used in clinical diagnostics, in medical imaging, as contrast agents in ultrasound imaging, and as transporters for targeted drug delivery. They can also be used to treat thrombosis, neoplastic diseases, open arteries and vascular plaques and for localized transport of chemotherapies in cancer patients. Microbubbles can be filled with any type of therapeutics, cure agents, growth factors, extracellular vesicles, exosomes, miRNAs, and drugs. Microbubbles protect their cargo from immune attack because of their specialized encapsulated shell composed of lipid and protein. Filled with curative medicine, they could effectively circulate through the whole body safely and efficiently to reach the target area. The advanced bubble-based drug-delivery system, integrated with artificial intelligence for guidance, holds great promise for the targeted delivery of drugs and medicines.

引用

页数：7

共 94 条

[1] Evaluation of the potential of doxorubicin loaded microbubbles as a theranostic modality using a murine tumor model [J].