Efficient synthesis of alkyl aryl ketones & ketals via palladium-catalyzed regioselective arylation of vinyl ethers

被引：32

作者：

Liu, Mingcui ^{[1
]}

Hyder, Zeynab ^{[2
]}

Sun, Yawei ^{[1
]}

Tang, Weijun ^{[1
]}

Xu, Lijin ^{[1
]}

Xiao, Jianliang ^{[2
]}

机构：

[1] Renmin Univ China, Dept Chem, Beijing 100872, Peoples R China

[2] Univ Liverpool, Dept Chem, Liverpool Ctr Mat & Catalysis, Liverpool L69 7ZD, Merseyside, England

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2010年 / 8卷 / 09期

基金：

中国国家自然科学基金;

关键词：

ELECTRON-RICH OLEFINS; OXIDATIVE HECK REACTIONS; CROSS-COUPLING REACTION; ENOL ETHERS; ACYL CHLORIDES; IONIC LIQUIDS; HETEROARYL HALIDES; ARYLBORONIC ACIDS; ROOM-TEMPERATURE; ALPHA-ARYLATION;

D O I：

10.1039/c001004a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The combination of Pd(OAc)(2) with 1,3-bis(diphenylphosphino)propane (dppp) in ethylene glycol constitutes a high-performance catalytic system for highly regioselective arylation of a range of electron-rich vinyl ethers by aryl bromides to provide, upon hydrolysis, alkyl aryl ketones and cyclic ketals in good yields with up to 3.75 x 10(5) TON and 15625 h(-1) TOF.

引用

页码：2012 / 2015

页数：4

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