Antimicrobial Lemongrass Essential Oil-Copper Ferrite Cellulose Acetate Nanocapsules

被引：25

作者：

Liakos, Ioannis L. ^{[1
]}

Abdellatif, Mohamed H. ^{[2
]}

Innocenti, Claudia ^{[3
,4
]}

Scarpellini, Alice ^{[5
]}

Carzino, Riccardo ^{[1
]}

Brunetti, Virgilio ^{[6
]}

Marras, Sergio ^{[5
]}

Brescia, Rosaria ^{[5
]}

Drago, Filippo ^{[5
]}

Pompa, Pier Paolo ^{[7
]}

机构：

[1] IIT, Nanophys Dept, Smart Mat Grp, Via Morego 30, I-16163 Genoa, Italy

[2] IIT, Nanostruct Dept, Via Morego 30, I-16163 Genoa, Italy

[3] Univ Florence, INSTM RU Florence, Via Lastruccia 3-13, I-50019 Florence, Italy

[4] Univ Florence, Dept Chem, Via Lastruccia 3-13, I-50019 Florence, Italy

[5] IIT, Nanochem Dept, Via Morego 30, I-16163 Genoa, Italy

[6] IIT, Biomol Nanotechnol, Via Barsanti 1, I-73010 Lecce, Italy

[7] IIT, Nanobiointeract & Nanodiagnost, Via Morego 30, I-16163 Genoa, Italy

来源：

MOLECULES | 2016年 / 21卷 / 04期

关键词：

antimicrobial nanocapsules; lemongrass essential oil; copper ferrite nanoparticles; cellulose acetate; drug delivery; antimicrobial resistance; ANTIBACTERIAL ACTIVITY; REACTION CHEMISTRY; ESCHERICHIA-COLI; NANOPARTICLES; EFFICIENCY; POLYMER; NANOSTRUCTURES; BIOFILMS; ALGINATE; THERAPY;

D O I：

10.3390/molecules21040520

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cellulose acetate (CA) nanoparticles were combined with two antimicrobial agents, namely lemongrass (LG) essential oil and Cu-ferrite nanoparticles. The preparation method of CA nanocapsules (NCs), with the two antimicrobial agents, was based on the nanoprecipitation method using the solvent/anti-solvent technique. Several physical and chemical analyses were performed to characterize the resulting NCs and to study their formation mechanism. The size of the combined antimicrobial NCs was found to be ca. 220 nm. The presence of Cu-ferrites enhanced the attachment of LG essential oil into the CA matrix. The magnetic properties of the combined construct were weak, due to the shielding of Cu-ferrites from the polymeric matrix, making them available for drug delivery applications where spontaneous magnetization effects should be avoided. The antimicrobial properties of the NCs were significantly enhanced with respect to CA/LG only. This work opens novel routes for the development of organic/inorganic nanoparticles with exceptional antimicrobial activities.

引用

页数：14

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