Pepsin-catalyzed vinylogous Michael addition of deconjugated butenolides and maleimides in water

被引：9
|
作者：
Zhang, Meng-Jie [1 ]
Li, Rui [1 ]
He, Yan-Hong [1 ]
Guan, Zhi [1 ]
机构：
[1] Southwest Univ, Key Lab Appl Chem Chongqing Municipal, Sch Chem & Chem Engn, Chongqing 400715, Peoples R China
来源：
CATALYSIS COMMUNICATIONS | 2017年 / 98卷
基金：
中国国家自然科学基金;
关键词：
Biocatalytic promiscuity; Vinylogous Michael reaction; Pepsin from porcine gastric mucous; Deconjugated butenolides; Maleimides; CARBON BOND FORMATION; ASPARTIC PROTEINASES; ORGANIC-REACTIONS; ALDOL REACTIONS; AQUEOUS-MEDIA; LIPASE; CONSTRUCTION; PROMISCUITY; PROTEASE; ENZYMES;
D O I：
10.1016/j.catcom.2017.03.021
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
A pepsin catalyzed vinylogous Michael addition of deconjugated butenolides and maleimides in water has been successfully achieved, and gamma,gamma-disubstituted butenolides were obtained in up to 98% yields with up to 99:1 dr.
引用
收藏
页码：85 / 89
页数：5
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