I2-Catalyzed intramolecular dehydrogenative aminooxygenation of alkynes to acylated imidazo [1,2-a]pyridines and indolizines

被引：23

作者：

He, Yimiao ^{[1
,2
]}

Yin, Wenqing ^{[1
,2
]}

Wang, Jian ^{[3
]}

Huang, Jianrong ^{[1
,2
]}

Pang, Xinru ^{[1
,2
]}

Gan, Chunfang ^{[1
,2
]}

Yang, Fang ^{[1
,2
]}

Huang, Chusheng ^{[1
,2
]}

机构：

[1] Guangxi Teachers Educ Univ, Coll Chem & Mat Sci, Nanning 530001, Peoples R China

[2] Guangxi Teachers Educ Univ, Guangxi Key Lab Nat Polymer Chem & Phys, Nanning 530001, Peoples R China

[3] Anhui Normal Univ, Coll Chem & Mat Sci, Anhui Lab Mol Based Mat, Minist Educ,Key Lab Funct Mol Solids, Wuhu, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2018年 / 5卷 / 11期

基金：

中国国家自然科学基金;

关键词：

OXIDATIVE COUPLING REACTIONS; METAL-FREE; C-H; UNACTIVATED ALKENES; DIFUNCTIONALIZATION; AMINOHYDROXYLATION; FUNCTIONALIZATION; AMINOPYRIDINES; DERIVATIVES; AMIDATION;

D O I：

10.1039/c8qo00063h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and green protocol for the synthesis of acylated imidazo[1,2-a]pyridines and indolizines via intramolecular dehydrogenative aminooxygenation of alkynes has been developed. The reaction proceeds smoothly utilizing I-2 as a catalyst and TBHP as an oxidant with a broad substrate scope. Mechanism studies reveal that the reaction maybe experiences a hydration followed by an oxidative cycloamination process.

引用

收藏

页码：1772 / 1776

页数：5

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