Metabolic Messengers: FGF21

被引：195

作者：

Flippo, Kyle H. ^{[1
,2
,3
]}

Potthoff, Matthew J. ^{[1
,2
,3
,4
]}

机构：

[1] Univ Iowa, Dept Neurosci & Pharmacol, Carver Coll Med, Iowa City, IA 52242 USA

[2] Univ Iowa, Fraternal Order Eagles Diabet Res Ctr, Carver Coll Med, Iowa City, IA 52242 USA

[3] Univ Iowa, Carver Coll Med, Iowa Neurosci Inst, Iowa City, IA 52242 USA

[4] Dept Vet Affairs Med Ctr, Iowa City, IA 52242 USA

来源：

NATURE METABOLISM | 2021年 / 3卷 / 03期

关键词：

GROWTH-FACTOR; 21; BETA-KLOTHO; PROTEIN-LEVERAGE; INSULIN SENSITIVITY; PPAR-ALPHA; ENERGY-EXPENDITURE; ADIPOSE-TISSUE; BODY-WEIGHT; CROSS-TALK; REGULATES METABOLISM;

D O I：

10.1038/s42255-021-00354-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Flippo and Potthoff provide a concise overview of the major physiological and pharmacological effects of FGF21 in nutrient and energy homeostasis. As a non-canonical fibroblast growth factor, fibroblast growth factor 21 (FGF21) functions as an endocrine hormone that signals to distinct targets throughout the body. Interest in therapeutic applications for FGF21 was initially sparked by its ability to correct metabolic dysfunction and decrease body weight associated with diabetes and obesity. More recently, new functions for FGF21 signalling have emerged, thus indicating that FGF21 is a dynamic molecule capable of regulating macronutrient preference and energy balance. Here, we highlight the major physiological and pharmacological effects of FGF21 related to nutrient and energy homeostasis and summarize current knowledge regarding FGF21's pharmacodynamic properties. In addition, we provide new perspectives and highlight critical unanswered questions surrounding this unique metabolic messenger.

引用

页码：309 / 317

页数：9

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