Antibiotics at the crossroads

被引:320
作者
Nathan, C
机构
[1] Cornell Univ, Weill Cornell Med Coll, Dept Microbiol & Immunol, New York, NY 10021 USA
[2] Cornell Univ, Weill Grad Sch Med Sci, Program Immunol, New York, NY 10021 USA
[3] Cornell Univ, Weill Grad Sch Med Sci, Program Mol Biol, New York, NY 10021 USA
关键词
D O I
10.1038/431899a
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Are we making the right choices to bring new drugs to the marketplace?
引用
收藏
页码:899 / 902
页数:4
相关论文
共 23 条
[1]   Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein [J].
Bryk, R ;
Lima, CD ;
Erdjument-Bromage, H ;
Tempst, P ;
Nathan, C .
SCIENCE, 2002, 295 (5557) :1073-1077
[2]  
*CDCP, 2000, PUBL HLTH ACT PLAN C
[3]   New approaches to the control of infections caused by antibiotic-resistant bacteria - An industry perspective [J].
Chopra, I ;
Hodgson, J ;
Metcalf, B ;
Poste, G .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1996, 275 (05) :401-403
[4]   The future challenges facing the development of new antimicrobial drugs [J].
Coates, A ;
Hu, YM ;
Bax, R ;
Page, C .
NATURE REVIEWS DRUG DISCOVERY, 2002, 1 (11) :895-910
[5]   The proteasome of Mycobacterium tuberculosis is required for resistance to nitric oxide [J].
Darwin, KH ;
Ehrt, S ;
Gutierrez-Ramos, JC ;
Weich, N ;
Nathan, CF .
SCIENCE, 2003, 302 (5652) :1963-1966
[6]   Antimalarial drug discovery: Efficacy models for compound screening [J].
Fidock, DA ;
Rosenthal, PJ ;
Croft, SL ;
Brun, R ;
Nwaka, S .
NATURE REVIEWS DRUG DISCOVERY, 2004, 3 (06) :509-520
[7]  
*GLOB ALL TUB DRUG, 2001, EC TB DRUG DEV
[8]  
Infectious Diseases Society of America, 2004, BAD BUGS NO DRUGS
[9]   Tapping into microbial diversity [J].
Keller, M ;
Zengler, K .
NATURE REVIEWS MICROBIOLOGY, 2004, 2 (02) :141-150
[10]   Antimicrobial drug discovery through bacteriophage genomics [J].
Liu, J ;
Dehbi, M ;
Moeck, G ;
Arhin, F ;
Bauda, P ;
Bergeron, D ;
Callejo, M ;
Ferretti, V ;
Ha, NH ;
Kwan, T ;
McCarty, J ;
Srikumar, R ;
Williams, D ;
Wu, JZJ ;
Gros, P ;
Pelletier, J ;
DuBow, M .
NATURE BIOTECHNOLOGY, 2004, 22 (02) :185-191