Endothelin receptor antagonists: which are the therapeutic perspectives in renal diseases?

被引:14
作者
Benigni, A [1 ]
Remuzzi, G [1 ]
机构
[1] Mario Negri Inst Pharmacol Res, I-24125 Bergamo, Italy
关键词
D O I
10.1093/ndt/13.1.5
中图分类号
R3 [基础医学]; R4 [临床医学];
学科分类号
1001 ; 1002 ; 100602 ;
摘要
Since the discovery of endothelin peptides, much interdisciplinary research looked into their unique profile as powerful and long-lasting vasoconstrictors and mitogens. On account of the renal vasculature's sensitivity to endothelin-l and the peptide's various effects on the kidney, the role of endothelin-l in the control of kidney function has attracted particular attention.
引用
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页码:5 / 7
页数:3
相关论文
共 14 条
[1]  
Benigni A, 1995, Curr Opin Nephrol Hypertens, V4, P349, DOI 10.1097/00041552-199507000-00011
[2]   The renoprotective potential of endothelin receptor antagonists [J].
Benigni, A ;
Remuzzi, G .
EXPERT OPINION ON THERAPEUTIC PATENTS, 1997, 7 (02) :139-149
[3]   Endothelin-1 transgenic mice develop glomerulosclerosis, interstitial fibrosis, and renal cysts but not hypertension [J].
Hocher, B ;
ThoneReineke, C ;
Rohmeiss, P ;
Schmager, F ;
Slowinski, T ;
Burst, V ;
Siegmund, F ;
Quertermous, T ;
Bauer, C ;
Neumayer, HH ;
Schleuning, WD ;
Theuring, F .
JOURNAL OF CLINICAL INVESTIGATION, 1997, 99 (06) :1380-1389
[4]   THE HUMAN ENDOTHELIN FAMILY - 3 STRUCTURALLY AND PHARMACOLOGICALLY DISTINCT ISOPEPTIDES PREDICTED BY 3 SEPARATE GENES [J].
INOUE, A ;
YANAGISAWA, M ;
KIMURA, S ;
KASUYA, Y ;
MIYAUCHI, T ;
GOTO, K ;
MASAKI, T .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (08) :2863-2867
[5]   ENDOTHELIN RECEPTOR SUBTYPE-B MEDIATES AUTOINDUCTION OF ENDOTHELIN-1 IN RAT MESANGIAL CELLS [J].
IWASAKI, S ;
HOMMA, T ;
MATSUDA, Y ;
KON, V .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (12) :6997-7003
[6]   Endothelins in the normal and diseased kidney [J].
Kohan, DE .
AMERICAN JOURNAL OF KIDNEY DISEASES, 1997, 29 (01) :2-26
[7]  
Nabokov A, 1996, NEPHROL DIAL TRANSPL, V11, P514
[8]   AN ENDOTHELIN-1 MEDIATED AUTOCRINE GROWTH LOOP INVOLVED IN HUMAN RENAL TUBULAR REGENERATION [J].
ONG, ACM ;
JOWETT, TP ;
FIRTH, JD ;
BURTON, S ;
KARET, FE ;
FINE, LG .
KIDNEY INTERNATIONAL, 1995, 48 (02) :390-401
[9]   EVIDENCE FOR ENDOTHELIN-INDUCED RENAL VASOCONSTRICTION INDEPENDENT OF ETA RECEPTOR ACTIVATION [J].
POLLOCK, DM ;
OPGENORTH, TJ .
AMERICAN JOURNAL OF PHYSIOLOGY, 1993, 264 (01) :R222-R226
[10]   ENDOTHELIN-1 STIMULATES ITS OWN SYNTHESIS IN HUMAN ENDOTHELIAL-CELLS [J].
SAIJONMAA, O ;
NYMAN, T ;
FYHRQUIST, F .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1992, 188 (01) :286-291