Applications of stem cell-derived exosomes in tissue engineering and neurological diseases

被引：44

作者：

Sun, Baichuan ^{[1
,2
]}

Peng, Jiang ^{[2
,3
,4
]}

Wang, Shoufeng ^{[1
]}

Liu, Xuejian ^{[1
]}

Zhang, Kaihong ^{[2
]}

Zhang, Zengzeng ^{[1
]}

Wang, Chong ^{[2
]}

Jing, Xiaoguang ^{[1
]}

Zhou, Chengfu ^{[1
]}

Wang, Yu ^{[2
,3
,4
]}

机构：

[1] Jiamusi Univ, Affiliated Hosp 1, Dept Orthoped 1, Jiamusi 154000, Peoples R China

[2] Chinese Peoples Liberat Army Gen Hosp, Inst Orthoped, Beijing 100853, Peoples R China

[3] Nantong Univ, Coinnovat Ctr Neuroregenerat, Nantong 226000, Peoples R China

[4] Beijing Key Lab Regenerat Med Orthopaed, Beijing 100853, Peoples R China

来源：

REVIEWS IN THE NEUROSCIENCES | 2018年 / 29卷 / 05期

基金：

国家重点研发计划;

关键词：

exosomes; extracellular vesicle; intercellular communication; neurological diseases; stem cell; tissue engineering; MESENCHYMAL STROMAL CELLS; PROMOTE TUMOR-GROWTH; COMPLEX CLASS-II; EXTRACELLULAR VESICLES; IN-VITRO; FUNCTIONAL RECOVERY; DRUG-DELIVERY; NEUROVASCULAR PLASTICITY; TRANSFERRIN RECEPTOR; PROTEOMIC ANALYSIS;

D O I：

10.1515/revneuro-2017-0059

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Exosomes are extracellular vesicles with diameters of 30-100 nm that are key for intercellular communication. Almost all types of cell, including dendritic cells, T cells, mast cells, epithelial cells, neuronal cells, adipocytes, mesenchymal stem cells, and platelets, can release exosomes. Exosomes are present in human body fluids, such as urine, amniotic fluid, malignant ascites, synovial fluid, breast milk, cerebrospinal fluid, semen, saliva, and blood. Exosomes have biological functions in immune response, antigen presentation, intercellular communication, and RNA and protein transfer. This review provides a brief overview of the origin, morphological characteristics, enrichment and identification methods, biological functions, and applications in tissue engineering and neurological diseases of exosomes.

引用

页码：531 / 546

页数：16

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