Thermal characterization of usnic acid/collagen-based films

被引：22

作者：

Nunes, Paula Santos ^{[1
]}

Bezerra, Marilia Santos ^{[1
]}

Costa, L. P. ^{[2
]}

Cardoso, Juliana Cordeiro ^{[3
]}

Albuquerque, R. L. C., Jr. ^{[3
]}

Rodrigues, M. O. ^{[2
]}

Barin, Gabriela Borin ^{[2
]}

da Silva, Francilene Amaral ^{[1
]}

Araujo, A. A. S. ^{[1
]}

机构：

[1] Univ Fed Sergipe, Dept Fisiol, BR-49100000 Sao Cristovao, Sergipe, Brazil

[2] Univ Fed Sergipe, Dept Quim, BR-49100000 Sao Cristovao, Sergipe, Brazil

[3] ITP, BR-49032490 Aracaju, Sergipe, Brazil

来源：

JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY | 2010年 / 99卷 / 03期

关键词：

Casting; Biodegradable films; Usnic acid; Collagen; Thermal characterization; DRUG-DELIVERY; COLLAGEN GEL; ACID;

D O I：

10.1007/s10973-009-0661-8

中图分类号：

O414.1 [热力学];

学科分类号：

摘要：

The purpose of this study was to evaluate the physical-chemical properties of collagen (CL) and usnic acid/collagen-based (UAC) films, using differential thermal analysis (DTA), thermogravimetry (TG/DTG), infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). Both films were prepared by casting process using polyethylene glycol 1500 (PEG 1500) as plasticizer. In the spectrum of UAC, similar bands of the usnic acid are observed, indicating that the polymerization (film formation) did not affect the stability of the drug. Distinctly, DTA curve of UAC did not show an endothermic peak at 201 A degrees C, indicative that the drug was incorporated into the polymeric system. These results were corroborated by the scanning electron microscopy (SEM). The TG/DTG curves of UAC presented a different thermal decomposition profile compared to the individual compounds and CL. These findings suggest the occurrence of molecular dispersion or solubilization of the drug in the collagen film.

引用

页码：1011 / 1014

页数：4

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