Calcium oxalate precipitation by diffusion using laminar microfluidics: toward a biomimetic model of pathological microcalcifications

被引：38

作者：

Laffite, G. ^{[1
,2
]}

Leroy, C. ^{[2
]}

Bonhomme, C. ^{[2
]}

Bonhomme-Coury, L. ^{[2
]}

Letavernier, E. ^{[3
]}

Daudon, M. ^{[3
]}

Frochot, V. ^{[3
]}

Haymann, J. P. ^{[3
]}

Rouziere, S. ^{[4
]}

Lucas, I. T. ^{[5
]}

Bazin, D. ^{[2
,4
]}

Babonneau, F. ^{[2
]}

Abou-Hassan, A. ^{[1
]}

机构：

[1] Univ Paris 06, Sorbonne Univ, UMR CNRS 8234, Lab Physicochim Electrolytes & Nanosyst Interfaci, 4 Pl Jussieu Case 51, F-75005 Paris, France

[2] Univ Paris 06, Sorbonne Univ, LCMCP, CNRS,Coll France, 11 Pl Marcelin Berthelot,Bat D, F-75005 Paris, France

[3] Univ Paris 06, Sorbonne Univ, Hop Tenon, AP HP,INSERM,Serv Explorat Fonct, 4 Rue Chine, F-75020 Paris, France

[4] Univ Paris 11, CNRS UMR 8502, Lab Phys Solides, Bat 510, F-91405 Orsay, France

[5] Univ Paris 06, Sorbonne Univ, UMR CNRS 8235, LISE, 4 Pl Jussieu,Case 133, F-75005 Paris, France

来源：

LAB ON A CHIP | 2016年 / 16卷 / 07期

关键词：

UROLITHIASIS; SPECTROSCOPY; TRIHYDRATE; DEVICES; URINE;

D O I：

10.1039/c6lc00197a

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of mixing calcium and oxalate precursors by diffusion at miscible liquid interfaces on calcium oxalate crystalline phases, and in physiological conditions (concentrations and flow rates), is studied using a microfluidic channel. This channel has similar dimensions as the collection duct in human kidneys and serves as a biomimetic model in order to understand the formation of pathological microcalcifications.

引用

页码：1157 / 1160

页数：4

共 27 条

[1]

[Anonymous], 2010, Introduction to Microfluidics

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