Recent progress in autophagic lysosome reformation

被引：86

作者：

Chen, Yang ^{[1
]}

Yu, Li ^{[1
]}

机构：

[1] Tsinghua Univ, Sch Life Sci, Tsinghua Univ Peking Univ Joint Ctr Life Sci, State Key Lab Membrane Biol, Beijing 100084, Peoples R China

来源：

TRAFFIC | 2017年 / 18卷 / 06期

基金：

中国国家自然科学基金;

关键词：

autophagic lysosome reformation (ALR); autophagy; clathrin; in vitro reconstitution; KIF5B; membrane deformation; phospholipid; MTOR REACTIVATION; TUBULATION; STARVATION; CLATHRIN; CELLS;

D O I：

10.1111/tra.12484

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Autophagic lysosome reformation (ALR) is the terminal step of autophagy and is essential for maintaining lysosome homeostasis during autophagy. During ALR, tubules are extruded from autolysosomes, and small vesicles named proto-lysosomes, which are composed of lysosomal membrane components, are generated from these tubules. Eventually, proto-lysosomes mature into functional lysosomes. In this review, we will summarize recent progress in understanding the regulation, mechanisms and physiological functions of ALR.

引用

页码：358 / 361

页数：4

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