Investigation of in-vitro biocompatibility and in-vivo biodegradability of AM series Mg alloys

被引：17

作者：

Comba, Arzu ^{[1
]}

Cicek, Bunyamin ^{[1
]}

Comba, Bahat ^{[1
]}

Sancak, Tunahan ^{[2
]}

Akveran, Gonul Arslan ^{[3
]}

Sun, Yavuz ^{[4
]}

Elen, Levent ^{[5
]}

Afshar, Milad Torkamanian ^{[2
]}

机构：

[1] Hitit Univ, Tech Sci Vocat Sch, Corum, Turkey

[2] Van Yuzuncu Yil Univ, Vet Fac, Van, Turkey

[3] Hitit Univ, Alaca Avni Cel Vocat Sch, Corum, Turkey

[4] Karabuk Univ, Engn Fac, Karabuk, Turkey

[5] Karabuk Univ, TOBB Vocat Sch, Karabuk, Turkey

来源：

MATERIALS TECHNOLOGY | 2022年 / 37卷 / 13期

关键词：

Mg alloy; in-vitro; in-vivo; biodegradability; biomaterial; biocompatibility; MAGNESIUM ALLOYS; MECHANICAL-PROPERTIES; BIOCORROSION BEHAVIOR; CORROSION BEHAVIOR; BONE-FORMATION; DEGRADATION; MICROSTRUCTURE; PHOSPHATE; STRENGTH; MODEL;

D O I：

10.1080/10667857.2022.2081115

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

In this study, in vitro/vivo biocompatibility experiments of Mg-Al-Mn alloy were carried out, and AM50 and AM60 alloys were used in the experiments. Immersion and potentiodynamic corrosion have been applied to these alloys in vitro. For biocompatibility, cytotoxicity test was performed. A total of 40 rats were used for the in-vivo experiment. AM series alloys were surgically placed in the femoral condyle as mini screws and monitored radiographically. AM alloys were removed together with the femur at the end of 7 weeks and further examined. After in-vivo application, the biodegradability level was successfully concluded with blood mineral analysis and urinalysis. In this study, the bioprocess of AM series Mg alloys with Al and Mn additions has been completed. As a result, the AM alloys used can be classified as biocompatible and biodegradable materials.

引用

页码：2819 / 2831

页数：13

共 68 条

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