A first-generation whole genome radiation hybrid map spanning the mouse genome

被引：157

作者：

McCarthy, LC

Terrett, J

Davis, ME

Knights, CJ

Smith, AL

Critcher, R

Schmitt, K

Hudson, J

Spurr, NK

Goodfellow, PN

机构：

[1] Univ Cambridge, Dept Genet, Cambridge CB2 3EH, England

[2] SmithKline Beecham Pharmaceut, Harlow CM19 5AW, Essex, England

[3] Millenium Pharmaceut, Cambridge, MA 02139 USA

[4] Res Genet Inc, Huntsville, AL 35801 USA

来源：

GENOME RESEARCH | 1997年 / 7卷 / 12期

关键词：

D O I：

10.1101/gr.7.12.1153

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have assembled a first-generation anchor map of the mouse genome using a panel of 94 whole-genome-radiation hybrids (WG-RHs) and 271 sequence-tagged sites (STSs). This is the first genome-wide RH anchor map of a model organism. All of the STSs have been previously localized on the genetic map and are located 8.8 Mb apart on average. This mouse WG-RH panel, known as T31, has an average retention frequency of 27.6% and an estimated potential resolution of 145 kb, making it a powerful resource for efficient large-scale expressed sequence tag mapping.

引用

页码：1153 / 1161

页数：9

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