The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness

被引：925
作者：
Sakurai, Takeshi [1 ]
机构：
[1] Univ Tsukuba, Inst Basic Med Sci, Dept Pharmacol, Tsukuba, Ibaraki 3058575, Japan
[2] Japan Sci & Technol Agcy, ERATO, Yanagisawa Orphan Receptor Project, Tokyo 1350064, Japan
来源：
NATURE REVIEWS NEUROSCIENCE | 2007年 / 8卷 / 03期
关键词：
D O I：
10.1038/nrn2092
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Sleep and wakefulness are regulated to occur at appropriate times that are in accordance with our internal and external environments. Avoiding danger and finding food, which are life-essential activities that are regulated by emotion, reward and energy balance, require vigilance and therefore, by definition, wakefulness. The orexin (hypocretin) system regulates sleep and wakefulness through interactions with systems that regulate emotion, reward and energy homeostasis.
引用
收藏
页码：171 / 181
页数：11
相关论文
共 108 条
  • [71] A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains
    Peyron, C
    Faraco, J
    Rogers, W
    Ripley, B
    Overeem, S
    Charnay, Y
    Nevsimalova, S
    Aldrich, M
    Reynolds, D
    Albin, R
    Li, R
    Hungs, M
    Pedrazzoli, M
    Padigaru, M
    Kucherlapati, M
    Fan, J
    Maki, R
    Lammers, GJ
    Bouras, C
    Kucherlapati, R
    Nishino, S
    Mignot, E
    [J]. NATURE MEDICINE, 2000, 6 (09) : 991 - 997
  • [72] Contributions of the amygdala to emotion processing: From animal models to human behavior
    Phelps, EA
    LeDoux, JE
    [J]. NEURON, 2005, 48 (02) : 175 - 187
  • [73] Neuropharmacological characterization of basal forebrain cholinergic stimulated cataplexy in narcoleptic canines
    Reid, MS
    Nishino, S
    Tafti, M
    Siegel, JM
    Dement, WC
    Mignot, E
    [J]. EXPERIMENTAL NEUROLOGY, 1998, 151 (01) : 89 - 104
  • [74] Centrally administered orexin-A activates corticotropin-releasing factor-containing neurons in the hypothalamic paraventricular nucleus and central amygdaloid nucleus of rats: possible involvement of central orexins on stress-activated central CRF neurons
    Sakamoto, F
    Yamada, S
    Ueta, Y
    [J]. REGULATORY PEPTIDES, 2004, 118 (03) : 183 - 191
  • [75] Input of orexin/hypocretin by a genetically encoded neurons revealed tracer in mice
    Sakurai, T
    Nagata, R
    Yamanaka, A
    Kawamura, H
    Tsujino, N
    Muraki, Y
    Kageyama, H
    Kunita, S
    Takahashi, S
    Goto, K
    Koyama, Y
    Shioda, S
    Yanagisawa, M
    [J]. NEURON, 2005, 46 (02) : 297 - 308
  • [76] Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior
    Sakurai, T
    Amemiya, A
    Ishii, M
    Matsuzaki, I
    Chemelli, RM
    Tanaka, H
    Williams, SC
    Richardson, JA
    Kozlowski, GP
    Wilson, S
    Arch, JRS
    Buckingham, RE
    Haynes, AC
    Carr, SA
    Annan, RS
    McNulty, DE
    Liu, WS
    Terrett, JA
    Elshourbagy, NA
    Bergsma, DJ
    Yanagisawa, M
    [J]. CELL, 1998, 92 (04) : 573 - 585
  • [77] Sakurai Takeshi, 2006, CNS & Neurological Disorders-Drug Targets, V5, P313, DOI 10.2174/187152706777452218
  • [78] The sleep switch: hypothalamic control of sleep and wakefulness
    Saper, CB
    Chou, TC
    Scammell, TE
    [J]. TRENDS IN NEUROSCIENCES, 2001, 24 (12) : 726 - 731
  • [79] Increased body-mass index in patients with narcolepsy
    Schuld, A
    Hebebrand, J
    Geller, F
    Pollmächer, T
    [J]. LANCET, 2000, 355 (9211) : 1274 - 1275
  • [80] Sherin JE, 1998, J NEUROSCI, V18, P4705
234567891011