Developmental toxicity induced during early stages of mammalian embryogenesis

被引:41
作者
Rutledge, JC
机构
[1] Univ Washington, Sch Med, Dept Lab Med, Seattle, WA 98105 USA
[2] Childrens Hosp & Med Ctr, Seattle, WA 98105 USA
关键词
zygote; mouse; mutagenesis; teratogenesis; mutagen; teratogen; birth defect; embryo; blastocyst; ethylmethane sulfonate; omphalocoele; exencephaly; skeletal defect; retinoic acid; hydrops; pre-gastrulation; implantation; mutagenicity testing; malformation; radiation;
D O I
10.1016/S0027-5107(97)00178-4
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Both a conceptual and a practical borderland between teratology and mutagenesis is early embryogenesis, the period between fertilization and gastrulation. Radiation and a variety of chemicals adversely affect the early conceptus leading to in utero mortality and malformations. The post-fertilization period of susceptibility differs from exposures of gametes, the later producing excessive pre-and peri-implantational death and low rates of fetal anomalies predominated by growth retardation. In contrast mutagen exposure of the zygote induces peri-implantional death, pan-gestational death and fetal anomalies predominated by hydrops, abdominal wall defects, and eye aberrations. The mechanism for this pathology remains unclear, These same agents produce a broader range of phenotypic anomalies during the remainder of pre-gastrulation development with anomalies overlapping those induced during organogenesis. Retinoic acid and 5-azacytidine administered prior to gastrulation produce novel malformation syndromes indicative of gene expression modification. The rates and types of defects from mutagen treatment of both gametes and the early conceptus contrast with those resulting from embryonic treatment during organogenesis, and the mechanisms are likely to differ. The pre-gastrulation period has not been explored to the extent reported during gametogenesis or organogenesis, Pre-gastrulation teratology is a new area of investigation with relevance both to reproductive toxicology and to mammalian developmental biology. (C) 1997 Elsevier Science B.V.
引用
收藏
页码:113 / 127
页数:15
相关论文
共 50 条
[21]   Role of aquaporins during teleost gametogenesis and early embryogenesis [J].
Chauvigne, Francois ;
Zapater, Cinta ;
Cerda, Joan .
FRONTIERS IN PHYSIOLOGY, 2011, 2
[22]   Early molecular effects of ethanol during vertebrate embryogenesis [J].
Yelin, Ronit ;
Kot, Hadas ;
Yelin, Dvir ;
Fainsod, Abraham .
DIFFERENTIATION, 2007, 75 (05) :393-403
[23]   Cryotop vitrification of porcine parthenogenetic embryos at the early developmental stages [J].
Wu, Guo-Quan ;
Quan, Guo-Bo ;
Shao, Qing-Yong ;
Lv, Chun-Rong ;
Jiang, Yan-Ting ;
Zhao, Zhi-Yong ;
Hong, Qiong-Hua .
THERIOGENOLOGY, 2016, 85 (03) :434-440
[24]   EXTRACELLULAR MATRIX-5 - ADHESIVE INTERACTIONS IN EARLY MAMMALIAN EMBRYOGENESIS, IMPLANTATION, AND PLACENTATION [J].
DAMSKY, C ;
SUTHERLAND, A ;
FISHER, S .
FASEB JOURNAL, 1993, 7 (14) :1320-1329
[25]   Severe malformations of eelpout (Zoarces viviparus) fry are induced by maternal estrogenic exposure during early embryogenesis [J].
Morthorst, Jane E. ;
Korsgaard, Bodil ;
Bjerregaard, Poul .
MARINE ENVIRONMENTAL RESEARCH, 2016, 113 :80-87
[26]   Textile dyes induce toxicity on zebrafish early life stages [J].
Rodrigues de Oliveira, Gisele Augusto ;
de Lapuente, Joaquin ;
Teixido, Elisabet ;
Porredon, Constanca ;
Borras, Miquel ;
de Oliveira, Danielle Palma .
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 2016, 35 (02) :429-434
[27]   EFFECT OF NEONATAL BLOOD-SERUM ON THE EARLY STAGES OF MOUSE EMBRYOGENESIS IN-VITRO [J].
ARKHANGELSKAYA, IB ;
SHTILBANS, VI ;
CHEBOTAR, NA ;
KOTIN, AM .
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 1994, 118 (07) :683-685
[28]   Analysis of Trace Elements During Different Developmental Stages of Somatic Embryogenesis in Plantago ovata Forssk Using Energy Dispersive X-ray Fluorescence [J].
Saha, Priyanka ;
Raychaudhuri, Sarmistha Sen ;
Sudarshan, Mathummal ;
Chakraborty, Anindita .
BIOLOGICAL TRACE ELEMENT RESEARCH, 2010, 135 (1-3) :283-294
[29]   Early developmental effects of propofol exposure in different stages of zebrafish embryos [J].
Felix, Luis ;
Campos, Sonia ;
de Pinho, Paula Guedes ;
Antunes, Luis ;
Valentim, Ana M. .
TOXICOLOGY LETTERS, 2025, 403 :84-93
[30]   Expression of serotonergic system components during early Xenopus embryogenesis [J].
Nikishin, Denis A. ;
Kremnyov, Stanislav V. ;
Konduktorova, Victoria V. ;
Shmukler, Yuri B. .
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, 2012, 56 (05) :385-391