Taming the mucosal immune response in Crohn's disease

被引：8
作者：
van Deventer, SJH [1 ]
机构：
[1] Univ Amsterdam, Acad Med Ctr, Dept Gastroenterol, NL-1105 AZ Amsterdam, Netherlands
来源：
BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY | 2002年 / 16卷 / 06期
关键词：
Crohn's disease; T lymphocyte; dendritic cell; apoptosis; IL-10; TNF; TGF beta; cytokines; mucosa; inflammation; gene therapy; tolerance;
D O I：
10.1053/bega.2002.0355
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
New effective therapeutic strategies for inflammatory bowel disease are based on recent knowledge of the regulation of the immune response. Specific defects of innate immunity, such as the NOD2 mutation in a subset of patients with Crohn's disease, have been associated with inflammatory bowel disease and provide new therapeutic targets. The ultimate therapeutic goal is the complete restoration of the mucosal immune balance and healing of all intestinal lesions. This may require repair of the underlying genetic mutation, restoration of defects of apoptosis, or generation of regulatory T-lymphocytes.
引用
收藏
页码：1035 / 1043
页数：9
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