Taming the mucosal immune response in Crohn's disease

被引：8

作者：

van Deventer, SJH ^{[1
]}

机构：

[1] Univ Amsterdam, Acad Med Ctr, Dept Gastroenterol, NL-1105 AZ Amsterdam, Netherlands

来源：

BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY | 2002年 / 16卷 / 06期

关键词：

Crohn's disease; T lymphocyte; dendritic cell; apoptosis; IL-10; TNF; TGF beta; cytokines; mucosa; inflammation; gene therapy; tolerance;

D O I：

10.1053/bega.2002.0355

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

New effective therapeutic strategies for inflammatory bowel disease are based on recent knowledge of the regulation of the immune response. Specific defects of innate immunity, such as the NOD2 mutation in a subset of patients with Crohn's disease, have been associated with inflammatory bowel disease and provide new therapeutic targets. The ultimate therapeutic goal is the complete restoration of the mucosal immune balance and healing of all intestinal lesions. This may require repair of the underlying genetic mutation, restoration of defects of apoptosis, or generation of regulatory T-lymphocytes.

引用

页码：1035 / 1043

页数：9

共 50 条

[21] Effect of Modulen vs budesonide on clinical response and mucosal healing in Crohn's patients [J].

Ovadia, Baruch ;

Niv, Eva ;

Katie, Sara Stern ;

Mahajna, Elisabeth ;

Gal, Oren ;

Kopelman, Yael .

WORLD JOURNAL OF GASTROENTEROLOGY, 2025, 31 (05)

[22] What predicts mucosal inflammation in Crohn's disease patients? [J].

Minderhoud, Itta M. ;

Samsom, Melvin ;

Oldenburg, Bas .

INFLAMMATORY BOWEL DISEASES, 2007, 13 (12) :1567-1572

[23] The Complex Relationship Between Microbiota, Immune Response and Creeping Fat in Crohn's Disease [J].

Suau, Roger ;

Pardina, Eva ;

Domenech, Eugeni ;

Loren, Violeta ;

Manye, Josep .

JOURNAL OF CROHNS & COLITIS, 2022, 16 (03) :472-489

[24] ECCO Position on Harmonisation of Crohn's Disease Mucosal Histopathology [J].

Magro, F. ;

Sabino, J. ;

Rosini, F. ;

Tripathi, M. ;

Borralho, P. ;

Baldin, P. ;

Danese, S. ;

Driessen, A. ;

Gordon, I. O. ;

Iacucci, M. ;

Noor, N. ;

Svrcek, M. ;

Peyrin-Biroulet, L. ;

Feakins, R. .

JOURNAL OF CROHNS & COLITIS, 2022, 16 (06) :876-883

[25] The Path to Crohn's Disease: Is Mucosal Pathology a Secondary Event? [J].

Behr, Marcel A. .

INFLAMMATORY BOWEL DISEASES, 2010, 16 (05) :896-902

[26] MUCOSAL FLORA IN CROHN'S DISEASE AND ULCERATIVE COLITIS - AN OVERVIEW [J].

Swidsinski, A. ;

Loening-Baucke, V. ;

Herber, A. .

JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2009, 60 :61-71

[27] Serum Amyloid A as a Surrogate Marker for Mucosal and Histologic Inflammation in Patients with Crohn's Disease [J].

Yarur, Andres J. ;

Quintero, Maria A. ;

Jain, Anjali ;

Czul, Frank ;

Barkin, Jamie S. ;

Abreu, Maria T. .

INFLAMMATORY BOWEL DISEASES, 2017, 23 (01) :158-164

[28] Accuracy of Magnetic Resonance Enterography in Assessing Response to Therapy and Mucosal Healing in Patients With Crohn's Disease [J].

Ordas, Ingrid ;

Rimola, Jordi ;

Rodriguez, Sonia ;

Paredes, Jose M. ;

Martinez-Perez, Maria J. ;

Blanc, Esther ;

Arevalo, Juan A. ;

Aduna, Marta ;

Andreu, Montserrat ;

Radosevic, Alexander ;

Ramirez-Morros, Anna M. ;

Pino, Susana ;

Gallego, Marta ;

Jauregui-Amezaga, Aranzazu ;

Ricart, Elena ;

Panes, Julian .

GASTROENTEROLOGY, 2014, 146 (02) :374-+

[29] Molecular pathogenesis of Crohn's disease [J].

Kustosz, Pawel ;

Durlik, Marek .

PRZEGLAD GASTROENTEROLOGICZNY, 2013, 8 (01) :21-26

[30] IMMUNE-MEDIATED MYOSITIS IN CROHN'S DISEASE [J].

Shimoyama, Takashi ;

Tamura, Yohei ;

Sakamoto, Tsuyoshi ;

Inoue, Kiyoharu .

MUSCLE & NERVE, 2009, 39 (01) :101-105

← 1 2 3 4 5 →