Delayed administration IL-1β neutralizing antibody improves cognitive function after transient global ischemia in rats

被引：6
作者：
Zhao, Bei [1 ]
Zou, Chang-jiang [2 ]
Zhou, Ping [1 ]
机构：
[1] Dali Univ, Sch Basic Med Sci, Dept Physiol & Pathophysiol, 2 Snowman Rd, Dali 671000, Yunnan, Peoples R China
[2] Peking Univ, Dept Physiol, Sch Med, 38 Xueyuan Rd, Beijing 100191, Peoples R China
来源：
BEHAVIOURAL BRAIN RESEARCH | 2016年 / 303卷
基金：
中国国家自然科学基金;
关键词：
IL-1; beta; Ischemia; Cognitive function; Motor function; Delayed administration; THERAPEUTIC STRATEGIES; CEREBRAL-ISCHEMIA; STROKE; INFLAMMATION; MECHANISMS; DAMAGE; INTERLEUKIN-1-BETA; CONSEQUENCES; PROTECTION; MICROGLIA;
D O I：
10.1016/j.bbr.2016.01.028
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
In order to study the protective effects on motor and cognitive function by inhibiting IL-1 beta as delayed as 24 h after global ischemia, we designed behavioral testing protocol and histology detection after 10 min transient global ischemia followed by IL-1 beta or its antibody intracerebroventricular injection. We found benefit of IL-1 beta antibody treatment 24 h after ischemia in cognitive function recovery. But no obvious amelioration in motor function was found. Further we detected cell morphology and survival by histology staining and proved IL-1 beta antibody could reduce ischemia induced cell morphological changes and cell loss in hippocampus, which related with cognitive function. Present results indicate intervening IL-1 beta pathway could be helpful in cognitive function recovery even as late as 24 h after ischemia happens. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：53 / 60
页数：8
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