Xanthone, benzophenone and bianthrone derivatives from the hypersaline lake-derived fungus Aspergillus wentii

被引：8

作者：

Form, Imke C. ^{[1
]}

Bonus, Michele ^{[2
]}

Gohlke, Holger ^{[2
]}

Lin, Wenhan ^{[3
]}

Daletos, Georgios ^{[1
]}

Proksch, Peter ^{[1
]}

机构：

[1] Heinrich Heine Univ Dusseldorf, Inst Pharmaceut Biol & Biotechnol, Univ Str 1, D-40225 Dusseldorf, Germany

[2] Heinrich Heine Univ Dusseldorf, Inst Pharmaceut & Med Chem, Univ Str 1, D-40225 Dusseldorf, Germany

[3] Peking Univ, Hlth Sci Ctr, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2019年 / 27卷 / 20期

关键词：

Aspergillus wentii; Bianthrone; DFT-based quantum chemical calculations; Structure elucidation; METABOLITES; STEREOCHEMISTRY; CONSTITUENTS; H-1;

D O I：

10.1016/j.bmc.2019.07.021

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Five new metabolites, including the xanthone derivative wentixanthone A (1), the benzophenone wentiphenone A (2), the diastereomeric mixtures of the bianthrones wentibianthrone A (3a, b) and wentibianthrone B (4a, b), as well as (10R, 10'S)-wentibianthrone C (5a) and (10R, 10'R)-wentibianthrone C (5b) were obtained from the fungus Aspergillus wentii, isolated from soil of the hypersaline lake El Hamra in Wadi El-Natrun, Egypt. The structures of the isolated compounds were established by one and two-dimensional NMR and MS spectroscopic analysis. The relative configuration of bianthrones (3-5) was elucidated by comparison of experimental and computed H-1 NMR chemical shifts. Results of biological assays are reported.

引用

页数：11

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