Mitochondrial genetics and disease

被引：144
作者：
Schon, EA
机构：
[1] Columbia Univ, Dept Neurol, New York, NY 10032 USA
[2] Columbia Univ, Dept Genet & Dev, New York, NY 10032 USA
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 2000年 / 25卷 / 11期
关键词：
D O I：
10.1016/S0968-0004(00)01688-1
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Mitochondrial respiratory chain diseases are a highly diverse group of disorders whose main unifying characteristic is the impairment of mitochondrial function. As befits an organelle containing gene products encoded by both mitochondrial DNA (mtDNA) and nuclear DNA (nDNA), these diseases can be caused by inherited errors in either genome, but a surprising number are sporadic, and a few are even caused by environmental factors.
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收藏
页码：555 / 560
页数：6
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