Pathophysiology of intestinal metaplasia of the stomach: emphasis on CDX2 regulation

被引：16
作者：
Barros, Rita [1 ]
Camilo, Vania [1 ]
Pereira, Bruno [1 ]
Freund, Jean-Noel [2 ]
David, Leonor [1 ]
Almeida, Raquel [1 ]
机构：
[1] Univ Porto, Fac Med, P-4200319 Oporto, Portugal
[2] INSERM, U682, F-67200 Strasbourg, France
来源：
BIOCHEMICAL SOCIETY TRANSACTIONS | 2010年 / 38卷
关键词：
bone morphogenetic protein (BMP); CDX2; Helicobacter pylori; intestinal metaplasia; mucin; stomach; HELICOBACTER-PYLORI INFECTION; HOMEODOMAIN PROTEIN CDX2; HOMEOBOX GENE; ABERRANT EXPRESSION; PROMOTER METHYLATION; ECTOPIC EXPRESSION; GASTRIC-CANCER; TRANSCRIPTION; CELLS; DIFFERENTIATION;
D O I：
10.1042/BST0380358
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
IM (intestinal metaplasia) of the stomach is a pre-neoplastic lesion that usually follows Helicobacter pylori infection and that confers increased risk for gastric cancer development. After setting the role played by CDX2 (Caudal-type homeobox 2) in the establishment of gastric IM, it became of foremost importance to unravel the regulatory mechanisms behind its de novo expression in the stomach. In the present paper, we review the basic pathology of gastric IM as well as the current knowledge on molecular pathways involved in CDX2 regulation in the gastric context.
引用
收藏
页码：358 / 363
页数：6
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