Activity of posaconazole against Pseudallescheria boydii:: In vitro and in vivo assays

被引：36

作者：

González, GM

Tijerina, R

Najvar, LK

Bocanegra, R

Rinaldi, MG

Loebenberg, D

Graybill, JR

机构：

[1] Univ Autonoma Nuevo Leon, Dept Microbiol, Fac Med, Monterrey 64460, Nuevo Leon, Mexico

[2] Univ Texas, Hlth Sci Ctr, Div Infect Dis 7881, Dept Med, San Antonio, TX 78229 USA

[3] Univ Texas, Hlth Sci Ctr, Dept Pathol, San Antonio, TX 78229 USA

[4] S Texas Vet Hlth Care Syst, Audie L Murphy Div, San Antonio, TX 78229 USA

[5] Schering Plough Corp, Inst Res, Kenilworth, NJ 07033 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2003年 / 47卷 / 04期

关键词：

D O I：

10.1128/AAC.47.4.1436-1438.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Thirty isolates of Pseudallescheria boydii were tested to compare the in vitro activity of posaconazole with those of fluconazole and itraconazole, using NCCLS methods. Posaconazole was evaluated in an immunosuppressed mouse model of disseminated pseudallescheriasis. Posaconazole was more effective than itraconazole and as effective as fluconazole in preventing death and significantly reducing the CFU of P. boydii from tissues.

引用

页码：1436 / 1438

页数：3

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