Concise two-step solution phase syntheses of four novel dihydroquinazoline scaffolds

被引：29

作者：

Dietrich, Justin ^{[1
,2
,3
]}

Kaiser, Christine

Meurice, Nathalie

Hulme, Christopher ^{[1
,2
,3
,4
]}

机构：

[1] Univ Arizona, Coll Pharm, Div Med Chem, Dept Pharm Tox, Tucson, AZ 85721 USA

[2] Univ Arizona, Coll Pharm, Div Organ Chem, Dept Pharm Tox, Tucson, AZ 85721 USA

[3] Univ Arizona, Inst BIO5, Tucson, AZ 85721 USA

[4] Univ Arizona, Dept Chem, Tucson, AZ 85721 USA

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 30期

关键词：

BIOAVAILABLE OXYTOCIN ANTAGONISTS; MULTICOMPONENT REACTIONS; MOLECULAR DIVERSITY; CCR5; ANTAGONISTS; DRUG DISCOVERY; HUMAN-GENOME; POTENT; 2,5-DIKETOPIPERAZINES; ISOCYANIDE; PHARMACOKINETICS;

D O I：

10.1016/j.tetlet.2010.05.108

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel two-step solution phase protocols for the synthesis of dihydroquinazolines and fused dihydroquinazoline-benzodiazepine tetracycles are reported. The methodology employs the Ugi reaction to assemble the desired diversity and acid treatment enables ring-closing transformations. The protocols are further facilitated by the use of microwave irradiation and n-butyl isocyanide to control the rate of each ring-forming transformation. Published by Elsevier Ltd.

引用

页码：3951 / 3955

页数：5

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