Lamotrigine as an augmentation agent in treatment-resistant obsessive-compulsive disorder: a case report

被引:39
作者
Uzun, Oe [1 ]
机构
[1] Gulhane Mil Med Acad, Dept Psychiat, TR-06018 Ankara, Turkey
关键词
glutamatergic agent; lamotrigine; obsessive-compulsive disorder; treatment-resistant; SEROTONIN; STRATEGIES; SCALE; OCD;
D O I
10.1177/0269881108098809
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Obsessive-compulsive disorder (OCD) is a relatively common, often chronic and disabling disorder with high rates of partial and/or absent response to standard, recommended treatments. We report a case of treatment-resistant OCD that was successfully treated with a pharmacological augmentation of lamotrigine plus clomipramine. The patient, a 59-year-old woman, was on a stable dose of clomipramine (225 mg/day) when she was started on lamotrigine (up to 150 mg/day). After 10 weeks of this treatment, her clinical condition remarkably improved, as indicated by a significant decrease of the Yale-Brown Obsessive-Compulsive Scale. This case suggests some preliminary evidence that the addition of glutamatergic agent lamotrigine may be useful in treatment-resistant OCD. However, further controlled studies are needed to support this finding.
引用
收藏
页码:425 / 427
页数:3
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