Highly diastereoselective conjugate addition of aryllithium to chiral β-nitrostyrene derivative:: An application to the asymmetric synthesis of 4-aryl-1,2,3,4-tetrahydroisoquinoline

被引：5

作者：

Asami, Masatoshi ^{[1
]}

Taketoshi, Ayako ^{[1
]}

Miyoshi, Keita ^{[1
]}

Hoshino, Hayato ^{[1
]}

Sakakibara, Kazuhisa ^{[1
]}

机构：

[1] Yokohama Natl Univ, Grad Sch Engn, Dept Adv Mat Chem, Hodogaya Ku, Yokohama, Kanagawa 2408501, Japan

来源：

CHEMISTRY LETTERS | 2007年 / 36卷 / 01期

关键词：

D O I：

10.1246/cl.2007.64

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Highly diastereoselective conjugate addition of aryllithium to beta-nitrostyrene derivative, having chiral acetal moiety derived from (S,S)- 1,2-bis(1-hydroxypropyl)benzene, was achieved. The adduct was transformed to 4-aryl-1,2,3,4-tetrahydroisoquinoline in high enantiomeric excess (ee).

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页码：64 / 65

页数：2

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