Prognostic significance of Ki-67 expression in transitional cell bladder carcinoma after radical cystectomy

被引：20

作者：

Suwa, Y

Takano, Y

Iki, M

Asakura, T

Noguchi, S

Masuda, M

机构：

[1] YOKOHAMA CITY UNIV,SCH MED,DEPT UROL,KANAZAWA KU,YOKOHAMA,KANAGAWA 236,JAPAN

[2] KITASATO UNIV,SCH MED,DEPT PATHOL,SAGAMIHARA,KANAGAWA 228,JAPAN

[3] FUKUI MED SCHOOK,DEPT ENVIRONM HLTH,YOSHIDA,FUKUI 91001,JAPAN

来源：

PATHOLOGY RESEARCH AND PRACTICE | 1997年 / 193卷 / 08期

关键词：

bladder neoplasms; cystectomy; Ki-67; antibody;

D O I：

10.1016/S0344-0338(97)80013-1

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

We evaluated the prognostic significance of the Ki-67 labeling index (Ki-67 LI) in 75 patients with transitional cell carcinoma of the bladder who underwent radical cystectomy. Immunohistochemical staining of archival material was performed by the streptavidin-biotin method. Univariate survival analysis showed that Ki-67 LI (p < 0.001), histologic grade (p < 0.05), tumor stage (p < 0.001) and the number of positive lymph nodes (p < 0.001) significantly con-elated with prognosis. Multivariate survival analysis indicated that the Ki-67 LI (p < 0.05), histologic grade (p < 0.01), tumor stage (p < 0.01), presence of lymph node metastases (p < 0.05) and use of neo-adjuvant therapy (p < 0.05) had independent prognostic value. The Ki-67 LI is an independent prognostic factor for patients with transitional cell bladder cancer treated by radical cystectomy.

引用

页码：551 / 556

页数：6

共 25 条

[1] LOCAL RECURRENCE AND SURVIVAL FOLLOWING NERVE-SPARING RADICAL CYSTOPROSTATECTOMY [J].

BRENDLER, CB ;

STEINBERG, GD ;

MARSHALL, FF ;

MOSTWIN, JL ;

WALSH, PC .

JOURNAL OF UROLOGY, 1990, 144 (05) :1137-1141

[2] PROLIFERATION IN HUMAN BLADDER-CARCINOMA MEASURED BY KI-67 ANTIBODY LABELING - ITS POTENTIAL CLINICAL IMPORTANCE [J].

BUSH, C ;

PRICE, P ;

NORTON, J ;

PARKINS, CS ;

BAILEY, MJ ;

BOYD, J ;

JONES, CR ;

AHERN, RP ;

HORWICH, A .

BRITISH JOURNAL OF CANCER, 1991, 64 (02) :357-360

[3] MONOCLONAL-ANTIBODY KI-67 IN THE STUDY OF THE PROLIFERATIVE ACTIVITY OF BLADDER-CARCINOMA [J].

FONTANA, D ;

BELLINA, M ;

GUBETTA, L ;

FASOLIS, G ;

ROLLE, L ;

SCOFFONE, C ;

PORPIGLIA, F ;

COLOMBO, M ;

TARABUZZI, R ;

LEONARDO, E .

JOURNAL OF UROLOGY, 1992, 148 (04) :1149-1151

[4] PRODUCTION OF A MOUSE MONOCLONAL-ANTIBODY REACTIVE WITH A HUMAN NUCLEAR ANTIGEN ASSOCIATED WITH CELL-PROLIFERATION [J].

GERDES, J ;

SCHWAB, U ;

LEMKE, H ;

STEIN, H .

INTERNATIONAL JOURNAL OF CANCER, 1983, 31 (01) :13-20

[5] MONOCLONAL-ANTIBODY TO 5-BROMODEOXYURIDINE AND 5-IODODEOXYURIDINE - A NEW REAGENT FOR DETECTION OF DNA-REPLICATION [J].

GRATZNER, HG .

SCIENCE, 1982, 218 (4571) :474-475

[6]

HERMANEK P, 1992, TNM CLASSIFICATION M, P154

[7] STUDY OF 365 CASES OF INFILTRATING BLADDER CANCER RELATION OF CERTAIN PATHOLOGICAL CHARACTERISTICS TO PROGNOSIS AFTER EXTIRPATION [J].

JEWETT, HJ ;

KING, LR ;

SHELLEY, WM .

JOURNAL OF UROLOGY, 1964, 92 (06) :668-&

[8]

KUBOTA Y, 1992, CANCER-AM CANCER SOC, V70, P2602, DOI 10.1002/1097-0142(19921201)70:11<2602::AID-CNCR2820701106>3.0.CO

[9]

2-W

[10] Five-year followup of a prospective trial of radical cystectomy and neoadjuvant chemotherapy: Nordic Cystectomy Trial I [J].

Malmstrom, PU ;

Rintala, E ;

Wahlqvist, R ;

Hellstrom, P ;

Hellsten, S ;

Hannisdal, E ;

Alfthan, O ;

Rusk, J ;

Opas, MA ;

Jauhiainen, K ;

Ottelin, J ;

Permi, J ;

Salmela, H ;

Tainio, H ;

Talja, M ;

Tuhkanen, K ;

Viitanen, J ;

Brevik, B ;

Hoeg, OM ;

Johannessen, NB ;

Farsund, T ;

Medby, PC ;

Muri, O ;

Fossa, SD ;

Ous, S ;

Sander, S ;

Tveter, KJ ;

Omland, H ;

Steinsvik, E ;

Urnes, T ;

Waaler, G ;

Ogreid, P ;

Ostrem, T ;

Andersson, L ;

Edsmyr, F ;

Ekman, P ;

Gustafson, H ;

Norming, U ;

Wijkstrom, H ;

Karlberg, L ;

Kihl, B ;

Lindeborg, T .

JOURNAL OF UROLOGY, 1996, 155 (06) :1903-1906

← 1 2 3 →