Advances of circular RNAs in carcinoma

被引：23
作者：
Xu, Xiao-yue [1 ]
Zhou, Lei-lei [2 ]
Yu, Chen [1 ]
Shen, Bo [1 ]
Feng, Ji-feng [1 ]
Yu, Shao-rong [1 ]
机构：
[1] Nanjing Med Univ, Affiliated Canc Hosp, Jiangsu Inst Canc Res, Jiangsu Canc Hosp, Nanjing, Jiangsu, Peoples R China
[2] Nanjing Med Univ, Affiliated Huaian Peoples Hosp 1, Dept Oncol, Nanjing, Jiangsu, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2018年 / 107卷
基金：
中国国家自然科学基金;
关键词：
CircRNAs; Cancer; ceRNAs; Biological functions; Biomarkers; REGULATES E-CADHERIN; BREAST-CANCER CELLS; HEPATOCELLULAR-CARCINOMA; PANCREATIC-CANCER; GASTRIC-CANCER; EXPRESSION; APOPTOSIS; GROWTH; BIOMARKER; MICRORNA;
D O I：
10.1016/j.biopha.2018.07.164
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Circular RNAs (circRNAs) are a type of non-coding RNAs with single-stranded closed structure. The rapid development of high-throughput sequencing technology has allowed for the widespread presence of circRNAs in transcriptomes. Moreover, increasing studies have identified a correlation between circRNAs and different cancers. In addition, most circRNAs are dysregulated in various cancers, and some of them have been reported be vital in the occurrence and development of tumors. For example, ciRS-7 plays a role in tumor promotion and circ-ITCH acts as a tumor suppressor. This review summarizes the latest progressions in the field regarding the functions of circRNAs in relation with cancers, and anticipates the emerging roles of circRNAs and future challenges in cancer research.
引用
收藏
页码：59 / 71
页数：13
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