Risk factors for post-COVID-19 condition in previously hospitalised children using the ISARIC Global follow-up protocol: a prospective cohort study

被引：229

作者：

Osmanov, Ismail M. ^{[1
,2
]}

Spiridonova, Ekaterina ^{[3
]}

Bobkova, Polina ^{[3
]}

Gamirova, Aysylu ^{[3
]}

Shikhaleva, Anastasia ^{[3
]}

Andreeva, Margarita ^{[3
]}

Blyuss, Oleg ^{[3
,4
]}

El-Taravi, Yasmin ^{[3
]}

DunnGalvin, Audrey ^{[3
,5
]}

Comberiati, Pasquale ^{[6
]}

Peroni, Diego G. ^{[6
]}

Apfelbacher, Christian ^{[7
]}

Genuneit, Jon ^{[8
]}

Mazankova, Lyudmila ^{[9
]}

Miroshina, Alexandra ^{[1
]}

Chistyakova, Evgeniya ^{[10
]}

Samitova, Elmira ^{[1
,9
]}

Borzakova, Svetlana ^{[2
,11
,12
]}

Bondarenko, Elena ^{[3
]}

Korsunskiy, Anatoliy A. ^{[3
]}

Konova, Irina ^{[1
]}

Hanson, Sarah Wulf ^{[13
]}

Carson, Gail ^{[14
]}

Sigfrid, Louise ^{[14
]}

Scott, Janet T. ^{[15
]}

Greenhawt, Matthew ^{[16
]}

Whittaker, Elizabeth A. ^{[17
]}

Garralda, Elena ^{[18
]}

Swann, Olivia, V ^{[19
,20
]}

Buonsenso, Danilo ^{[21
,22
,23
]}

Nicholls, Dasha E. ^{[18
]}

Simpson, Frances ^{[24
]}

Jones, Christina ^{[25
]}

Semple, Malcolm G. ^{[26
,27
]}

Warner, John O. ^{[28
]}

Vos, Theo ^{[13
]}

Olliaro, Piero ^{[14
]}

Munblit, Daniel ^{[3
,28
,29
]}

机构：

[1] ZA Bashlyaeva Childrens Municipal Clin Hosp, Moscow, Russia

[2] Pirogov Russian Natl Res Med Univ, Moscow, Russia

[3] Sechenov First Moscow State Med Univ, Inst Childs Hlth, Dept Paediat & Paediat Infect Dis, Sechenov Univ, Moscow, Russia

[4] Univ Hertfordshire, Sch Phys Astron & Math, Hatfield, Herts, England

[5] Univ Coll Cork, Sch Appl Psychol, Cork, Ireland

[6] Univ Pisa, Dept Clin & Expt Med, Sect Pediat, Pisa, Italy

[7] Otto von Guericke Univ, Fac Med, Inst Social Med & Hlth Syst Res, Magdeburg, Germany

[8] Univ Leipzig, Med Fac, Dept Pediat, Pediat Epidemiol, Leipzig, Germany

[9] Minist Healthcare Russian Federat, Russian Med Acad Continuous Profess Educ, Moscow, Russia

[10] Sechenov First Moscow State Med Univ, Inst Childs Hlth, Dept Paediat & Paediat Rheumatol, Sechenov Univ, Moscow, Russia

[11] Res Inst Healthcare Org, Moscow, Russia

[12] Med Management Moscow Healthcare Dept, Moscow, Russia

[13] Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98195 USA

[14] Univ Oxford, ISARIC Global Support Ctr, Nuffield Dept Med, Oxford, England

[15] Univ Glasgow, Ctr Virus Res, MRC, Glasgow, Lanark, Scotland

[16] Univ Colorado, Childrens Hosp Colorado, Dept Pediat, Sect Allergy Immunol,Sch Med, Aurora, CO USA

[17] Imperial Coll Healthcare NHS Trust, Paediat Infect Dis, London, England

[18] Imperial Coll London, Div Psychiat, London, England

[19] Univ Edinburgh, Dept Child Life & Hlth, Edinburgh, Midlothian, Scotland

[20] Royal Hosp Children, Paediat Infect Dis, Glasgow, Lanark, Scotland

[21] Fdn Policlin Univ A Gemelli IRCCS, Dept Woman & Child Hlth & Publ Hlth, Rome, Italy

[22] Univ Cattolica Sacro Cuore, Clin Intensivol & Perioperatorie, Dipartimento Sci Biotecnol Base, Rome, Italy

[23] Univ Cattolica Sacro Cuore, Ctr Global Hlth Res & Studies, Rome, Italy

[24] Coventry Univ, Coventry, W Midlands, England

[25] Univ Surrey, Fac Hlth & Med Sci, Sch Psychol, Guildford, Surrey, England

[26] Univ Liverpool, Fac Hlth & Life Sci, Inst Infect Vet & Ecol Sci, Hlth Protect Res Unit Emerging & Zoonot Infect, Liverpool, Merseyside, England

[27] Alder Hey Childrens Hosp, Dept Resp Med, Liverpool, Merseyside, England

[28] Imperial Coll London, Fac Med, Natl Heart & Lung Inst, Inflammat Repair & Dev Sect, London, England

[29] Res & Clin Ctr Neuropsychiat, Moscow, Russia

来源：

EUROPEAN RESPIRATORY JOURNAL | 2022年 / 59卷 / 02期

关键词：

COVID-19;

D O I：

10.1183/13993003.01341-2021

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Background The long-term sequelae of coronavirus disease 2019 (COVID-19) in children remain poorly characterised. This study aimed to assess long-term outcomes in children previously hospitalised with COVID-19 and associated risk factors. Methods This is a prospective cohort study of children (<= 18 years old) admitted to hospital with confirmed COVID-19. Children admitted between 2 April 2020 and 26 August 2020 were included. Telephone interviews used the International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) COVID-19 Health and Wellbeing Follow-up Survey for Children. Persistent symptoms (>5 months) were further categorised by system(s) involved. Results 518 out of 853 (61%) eligible children were available for the follow-up assessment and included in the study. Median (interquartile range (IQR)) age was 10.4 (3-15.2) years and 270 (52.1%) were girls. Median (IQR) follow-up since hospital discharge was 256 (223-271) days. At the time of the follow-up interview 126 (24.3%) participants reported persistent symptoms, among which fatigue (53, 10.7%), sleep disturbance (36, 6.9%) and sensory problems (29, 5.6%) were the most common. Multiple symptoms were experienced by 44 (8.4%) participants. Risk factors for persistent symptoms were: older age "6-11 years" (OR 2.74, 95% CI 1.37-5.75) and "12-18 years" (OR 2.68, 95% CI 1.41-5.4), and a history of allergic diseases (OR 1.67, 95% CI 1.04-2.67). Conclusions A quarter of children experienced persistent symptoms months after hospitalisation with acute COVID-19 infection, with almost one in 10 experiencing multisystem involvement. Older age and allergic diseases were associated with higher risk of persistent symptoms at follow-up.

引用

页数：11

共 26 条

[1] Covid-19 hyperinflammation and post-Covid-19 illness may be rooted in mast cell activation syndrome [J].

Afrin, Lawrence B. ;

Weinstock, Leonard B. ;

Molderings, Gerhard J. .

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2020, 100 :327-332

[2]

[Anonymous], 2020, LANCET, V396, P1861, DOI 10.1016/S0140-6736(20)32662-3

[3] Meeting the challenge of long COVID [J].

不详 .

NATURE MEDICINE, 2020, 26 (12) :1803-1803

[4] Post-covid syndrome in individuals admitted to hospital with covid-19: retrospective cohort study [J].

Ayoubkhani, Daniel ;

Khunti, Kamlesh ;

Nafilyan, Vahe ;

Maddox, Thomas ;

Humberstone, Ben ;

Diamond, Ian ;

Banerjee, Amitava .

BMJ-BRITISH MEDICAL JOURNAL, 2021, 372

[5]

Buonsenso D, 2021, ACTA PAEDIATR, V110, P2208, DOI [10.1111/apa.15870, 10.1016/j.jrurstud.2021.07.019]

[6] Somatic Complaints in Anxious Youth [J].

Crawley, Sarah A. ;

Caporino, Nicole E. ;

Birmaher, Boris ;

Ginsburg, Golda ;

Piacentini, John ;

Albano, Anne Marie ;

Sherrill, Joel ;

Sakolsky, Dara ;

Compton, Scott N. ;

Rynn, Moira ;

McCracken, James ;

Gosch, Elizabeth ;

Keeton, Courtney ;

March, John ;

Walkup, John T. ;

Kendall, Philip C. .

CHILD PSYCHIATRY & HUMAN DEVELOPMENT, 2014, 45 (04) :398-407

[7] Characterizing long COVID in an international cohort: 7 months of symptoms and their impact [J].

Davis, Hannah E. ;

Assaf, Gina S. ;

McCorkell, Lisa ;

Wei, Hannah ;

Low, Ryan J. ;

Re'em, Yochai ;

Redfield, Signe ;

Austin, Jared P. ;

Akrami, Athena .

ECLINICALMEDICINE, 2021, 38

[8] Management of post-acute covid-19 in primary care [J].

Greenhalgh, Trisha ;

Knight, Matthew ;

A'Court, Christine ;

Buxton, Maria ;

Husain, Laiba .

BMJ-BRITISH MEDICAL JOURNAL, 2020, 370

[9] The REDCap consortium: Building an international community of software platform partners [J].

Harris, Paul A. ;

Taylor, Robert ;

Minor, Brenda L. ;

Elliott, Veida ;

Fernandez, Michelle ;

O'Neal, Lindsay ;

McLeod, Laura ;

Delacqua, Giovanni ;

Delacqua, Francesco ;

Kirby, Jacqueline ;

Duda, Stephany N. .

JOURNAL OF BIOMEDICAL INFORMATICS, 2019, 95

[10] Research electronic data capture (REDCap)-A metadata-driven methodology and workflow process for providing translational research informatics support [J].

Harris, Paul A. ;

Taylor, Robert ;

Thielke, Robert ;

Payne, Jonathon ;

Gonzalez, Nathaniel ;

Conde, Jose G. .

JOURNAL OF BIOMEDICAL INFORMATICS, 2009, 42 (02) :377-381

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