Outcomes of mucosal melanoma of the head and neck

被引：6

作者：

Frakes, Jessica M. ^{[1
]}

Strom, Tobin J. ^{[1
]}

Naghavi, Arash O. ^{[1
]}

Trotti, Andy ^{[1
]}

Rao, Nikhil G. ^{[1
]}

McCaffrey, Judith C. ^{[2
]}

Otto, Kristen J. ^{[2
]}

Padhya, Tapan ^{[2
]}

Caudell, Jimmy J. ^{[1
]}

机构：

[1] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Dept Radiat Oncol, 12902 Magnolia Dr, Tampa, FL 33612 USA

[2] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Dept Head & Neck & Endocrine Oncol, Tampa, FL 33612 USA

来源：

JOURNAL OF MEDICAL IMAGING AND RADIATION ONCOLOGY | 2016年 / 60卷 / 02期

关键词：

head and neck; mucosal melanoma; outcomes; radiotherapy; targeted agents; CUTANEOUS MELANOMA; RADIOTHERAPY; CANCER; TRIAL;

D O I：

10.1111/1754-9485.12404

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

IntroductionMucosal melanoma of the head and neck is a rare disease with limited data available on outcomes; therefore, we reviewed our institutional experience. MethodsAn institutional database was queried and 38 patients with head and neck mucosal melanoma were identified. Charts were abstracted and local control (LC), progression-free survival (PFS) and overall survival (OS) were calculated. ResultsMost patients had T4 disease (86%), although nodes were positive in 11%. En bloc or endoscopic resection was performed on 93%. Adjuvant or definitive radiotherapy to a median dose of 60Gy was utilized in 90%. Chemotherapy was given in 21%, and 16% received interferon. Three-year LC, PFS and OS were 90%, 48% and 59%, respectively. Median OS was 4.6 years. Site of first failure was distant in 52% of cases. ConclusionWith aggressive therapy median OS was 4.6 years in this cohort. Distant recurrence remains the primary mode of failure. It may be reasonable to include mucosal melanoma patients in trials of systemic agents along with high-risk cutaneous melanomas.

引用

页码：268 / 273

页数：6

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