New insights into a complex fungal pathogen: the case of Paracoccidioides spp.

被引：31

作者：

Gonzalez, Angel ^{[1
]}

Hernandez, Orville ^{[1
]}

机构：

[1] Univ Antioquia, Sch Microbiol, Basic & Appl Microbiol Res Grp MICROBA, Calle 70 52-72,Of 607, Medellin, Colombia

来源：

YEAST | 2016年 / 33卷 / 04期

关键词：

Paracoccidioides brasiliensis; Paracoccidioides lutzii; paracoccidioidomycosis; virulence factors; metabolic pathways; host defense mechanisms; CD8(+) T-CELLS; EXTRACELLULAR-MATRIX PROTEINS; ACTIVATED MURINE MACROPHAGES; BRASILIENSIS INFECTION; NITRIC-OXIDE; PULMONARY PARACOCCIDIOIDOMYCOSIS; IFN-GAMMA; MOLECULAR-IDENTIFICATION; IMMUNE-RESPONSE; TNF-ALPHA;

D O I：

10.1002/yea.3147

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Paracoccidioidomycosis is a systemic mycosis endemic to Latin America, with Paracoccidioides brasiliensis and P. lutzii being the causal agents of this disorder. Several issues have been raised in the 100 years since its discovery and in this article we discuss features of this fascinating fungal pathogen, including its biology, eco-epidemiology and aspects of its pathogenicity. We also consider some of its virulence determinants, the most recent advances in the study of its metabolic pathways and the molecular and genetic research tools developed for this research. We also review the animal models used to study host-fungal interactions and how the host defence mechanisms against this pathogen work. Copyright (c) 2015 John Wiley & Sons, Ltd.

引用

页码：113 / 128

页数：16

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