Acid-base equilibria in solutions of cephotaxime and cephtriaxone

被引：3

作者：

Alekseev, V. G. ^{[1
]}

Vorob'ev, N. V. ^{[1
]}

Yakubovich, Yu. Ya. ^{[1
]}

机构：

[1] Tver State Univ, Tver 170002, Russia

来源：

RUSSIAN JOURNAL OF PHYSICAL CHEMISTRY | 2006年 / 80卷 / 09期

关键词：

D O I：

10.1134/S0036024406090123

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The concentration constants of acid-base equilibria in aqueous solutions of cephotaxime and cephtriaxone were determined pH-metrically at 20 degrees C against the background of 0.1, 0.4, 0.7, and 1.0 M solutions of KCl and KNO3. The thermodynamic constants of these equilibria were calculated by the extrapolation of the concentration constants to zero ionic strength according to the Huckel equation. Cephotaxime and cephtriaxone ionic form sizes were calculated by the semiempirical PM3 method for energetically favorable conformations.

引用

页码：1428 / 1432

页数：5

共 15 条

[1]

Agafonov AV, 2005, RUSS J PHYS CHEM+, V79, P403

[2]

Bates R.G., 1964, Determination of pH. Theory and Practice

[3] Measurement of pH. Definition, standards, and procedures [J].

Buck, RP ;

Rondinini, S ;

Covington, AK ;

Baucke, FGK ;

Brett, CMA ;

Camoes, MF ;

Milton, MJT ;

Mussini, T ;

Naumann, R ;

Pratt, KW ;

Spitzer, P ;

Wilson, GS .

PURE AND APPLIED CHEMISTRY, 2002, 74 (11) :2169-2200

[4]

Daniele P.G., 1997, CURR TOP SOL CHEM, V2, P253

[5] Determination of the dissociation constants of the cephalosporins cefepime and cefpirome using UV spectrometry and pH potentiometry [J].

Evagelou, V ;

Tsantili-Kakoulidou, A ;

Koupparis, M .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2003, 31 (06) :1119-1128

[6] OVERLAPPING IONIZATION-CONSTANTS FOR CEFOTAXIME [J].

FABRE, H ;

EDDINE, NH ;

BERGE, G ;

BLANCHIN, MD .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1985, 74 (01) :85-86

[7]

FEDOROV VA, 1976, ZH FIZ KHIM+, V50, P2213

[8]

Filippov DV, 2003, RUSS J INORG CHEM+, V48, P772

[9]

Gordon J. E., 1975, ORGANIC CHEM ELECTRO

[10] Determination of dissociation constants of cephalosporins by capillary zone electrophoresis [J].

Mrestani, Y ;

Neubert, R ;

Munk, A ;

Wiese, M .

JOURNAL OF CHROMATOGRAPHY A, 1998, 803 (1-2) :273-278

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