Photofunctional Nanomodulators for Bioexcitation

被引：72

作者：

Miyako, Eijiro ^{[1
]}

Russier, Julie ^{[2
]}

Mauro, Matteo ^{[3
,4
]}

Cebrian, Cristina ^{[3
,4
]}

Yawo, Hiromu ^{[5
]}

Menard-Moyon, Cecilia ^{[2
]}

Hutchison, James A. ^{[4
,6
]}

Yudasaka, Masako ^{[1
]}

Iijima, Sumio ^{[1
]}

De Cola, Luisa ^{[3
,4
]}

Bianco, Alberto ^{[2
]}

机构：

[1] Natl Inst Adv Ind Sci & Technol, Nanotube Res Ctr NTRC, Tsukuba, Ibaraki 3058565, Japan

[2] CNRS, Inst Biol Mol & Cellulaire, Lab Immunopathol & Chim Therapeut, F-67084 Strasbourg, France

[3] Univ Strasbourg, Lab Chim & Biomat Supramol, ISIS, F-67083 Strasbourg, France

[4] Univ Strasbourg, CNRS, F-67083 Strasbourg, France

[5] Tohoku Univ, Grad Sch Life Sci, Dept Dev Biol & Neurosci, Sendai, Miyagi 9808577, Japan

[6] Univ Strasbourg, Lab Nanostruct, ISIS, F-67083 Strasbourg, France

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2014年 / 53卷 / 48期

关键词：

biological activity; laser chemistry; nanomaterials; nanotechnology; CARBON NANOHORNS; NEURONS; ROS;

D O I：

10.1002/anie.201407169

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A single organism comprises diverse types of cells. To acquire a detailed understanding of the biological functions of each cell, comprehensive control and analysis of homeostatic processes at the single-cell level are required. In this study, we develop a new type of light-driven nanomodulator comprising dye-functionalized carbon nanohorns (CNHs) that generate heat and reactive oxygen species under biologically transparent near-infrared (NIR) laser irradiation. By exploiting the physicochemical properties of the nanohorns, cellular calcium ion flux and membrane currents were successfully controlled at the single-cell level. In addition, the nanomodulator allows a remote bioexcitation of tissues during NIR laser exposure making this system a powerful tool for single-cell analyses and innovative cell therapies.

引用

页码：13121 / 13125

页数：5

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