Azide-Enolate 1,3-Dipolar Cycloaddition as an Efficient Approach for the Synthesis of 1,5-Disubstituted 1,2,3-Triazoles from Alkyl/Aryl Azides and β-Ketophosphonates

被引:34
作者
Gonzalez-Calderon, Davir [1 ]
Fuentes-Benites, Aydee [1 ]
Diaz-Torres, Eduardo [2 ]
Gonzalez-Gonzalez, Carlos A. [1 ]
Gonzalez-Romero, Carlos [1 ]
机构
[1] Univ Autonoma Estado Mexico, Fac Quim, Dept Quim Organ, Paseo Colon Paseo Tollocan S-N, Toluca 50120, Estado De Mexic, Mexico
[2] Univ Nacl Autonoma Mexico, Inst Quim, Circuito Exterior S-N,Ciudad Univ, Mexico City 04510, DF, Mexico
关键词
Azides; Enolates; Cycloaddition; Nitrogen heterocycles; beta-Ketophosphonates; RUTHENIUM-CATALYZED CYCLOADDITION; METAL-FREE SYNTHESIS; REGIOSELECTIVE SYNTHESIS; ONE-POT; ORGANOCATALYTIC SYNTHESIS; REGIOSPECIFIC SYNTHESIS; TERMINAL ALKYNES; DIRECT ACCESS; ARYL AZIDES; INHIBITORS;
D O I
10.1002/ejoc.201501465
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A simple procedure to prepare 1,5-disubstituted 1,2,3-triazoles efficiently from alkyl/aryl azides and beta-ketophosphonates in the presence of KOH by an azide-enolate 1,3-dipolar cycloaddition in good yields was developed.
引用
收藏
页码:668 / 672
页数:5
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