Regulatory T cells and immune tolerance to tumors

被引：60

作者：

Cao, Xuefang ^{[1
]}

机构：

[1] Roswell Pk Canc Inst, Dept Immunol, Buffalo, NY 14263 USA

来源：

IMMUNOLOGIC RESEARCH | 2010年 / 46卷 / 1-3期

关键词：

Regulatory T cells (Tregs); Self-tolerance; Tumor immunity; Tumor micro-environment; Immunotherapy; PLASMACYTOID DENDRITIC CELLS; IMMUNOLOGICAL SELF-TOLERANCE; TGF-BETA; IN-VIVO; MEDIATED SUPPRESSION; NATURAL-KILLER; NK CELLS; TRYPTOPHAN CATABOLISM; OVARIAN-CARCINOMA; CUTTING EDGE;

D O I：

10.1007/s12026-009-8124-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immune cells infiltrate tumors and make up a significant component of the multicellular cancer micro-environment, yet the immune system often fails to prevent tumor formation and progression. One explanation for this paradox is the presence of tolerance-promoting regulatory T cells (Tregs) that counteract antitumor immune cells. Tregs were known to be essential for maintaining self-tolerance. Recently, Tregs have been found to promote tolerance to tumors in mouse models. Moreover, Treg infiltration in human tumors and malignant ascites is associated with worse clinical outcomes for various types of cancers. As many reviews have discussed the development and function of Tregs, this review focuses on the cellular and molecular mechanisms by which Tregs influence antitumor immune responses, and also discusses how these mechanisms might be exploited to develop innovative immune-based approaches that can improve cancer therapy.

引用

页码：79 / 93

页数：15

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