The GLUT4 glucose transporter

被引：1077
作者：
Huang, Shaohui [1 ]
Czech, Michael P. [1 ]
机构：
[1] Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01605 USA
来源：
CELL METABOLISM | 2007年 / 5卷 / 04期
关键词：
D O I：
10.1016/j.cmet.2007.03.006
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Few physiological parameters are more tightly and acutely regulated in humans than blood glucose concentration. The major cellular mechanism that diminishes blood glucose when carbohydrates are ingested is insulin-stimulated glucose transport into skeletal muscle. Skeletal muscle both stores glucose as glycogen and oxidizes it to produce energy following the transport step. The principal glucose transporter protein that mediates this uptake is GLUT4, which plays a key role in regulating whole body glucose homeostasis. This review focuses on recent advances on the biology of GLUT4.
引用
收藏
页码：237 / 252
页数：16
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