Hydroxamate-based inhibitors of low affinity IgE receptor (CD23) processing

被引：16

作者：

Bailey, S

Bolognese, B

Buckle, DR

Faller, A

Jackson, S

Louis-Flamberg, P

McCord, M

Mayer, RJ

Marshall, LA

Smith, DG

机构：

[1] SmithKline Beecham Pharmaceut, Epsom KT18 5XG, Surrey, England

[2] SmithKline Beecham Pharmaceut, King Of Prussia, PA 19402 USA

[3] SmithKline Beecham Pharmaceut, Harlow CM19 5AW, Essex, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 01期

关键词：

D O I：

10.1016/S0960-894X(97)10148-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of hydroxamic acids related to the non-selective matrix metalloprotease inhibitor Batimastat is described, which inhibits the proteolytic cleavage of the low affinity IgE receptor from cell membrane preparations. Limited SAR studies suggest that the structural requirements for effective inhibition ate distinct from those required for the inhibition of collagenase. (C) 1997 Elsevier Science Ltd. All rights reserved.

引用

页码：23 / 28

页数：6

共 20 条

[1]

BECKETT RP, 1993, SYNLETT, P137

[2] Recent advances in matrix metalloproteinase inhibitor research [J].