Development and regeneration of vestibular hair cells in mammals

被引：79

作者：

Burns, Joseph C. ^{[1
]}

Stone, Jennifer S. ^{[2
,3
]}

机构：

[1] Decibel Therapeut, 215 First St,Suite 430, Cambridge, MA 02142 USA

[2] Univ Washington, Sch Med, Dept Otorhinolaryngol Head & Neck Surg, Box 357923, Seattle, WA 98195 USA

[3] Univ Washington, Sch Med, Virginia Merrill Bloedel Hearing Res Ctr, Box 357923, Seattle, WA 98195 USA

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2017年 / 65卷

基金：

美国国家卫生研究院;

关键词：

Vestibular; Hair cell; Supporting cell; Development; Regeneration; MOUSE INNER-EAR; PERIPHERAL INNERVATION PATTERNS; ZEBRAFISH LATERAL-LINE; AVIAN AUDITORY EPITHELIUM; PLURIPOTENT STEM-CELLS; HUMAN UTRICULAR MACULA; GROWTH-FACTOR-ALPHA; MATH1; GENE-TRANSFER; MATURE GUINEA-PIGS; SUPPORTING CELLS;

D O I：

10.1016/j.semcdb.2016.11.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Vestibular sensation is essential for gaze stabilization, balance, and perception of gravity. The vestibular receptors in mammals, Type I and Type II hair cells, are located in five small organs in the inner ear. Damage to hair cells and their innervating neurons can cause crippling symptoms such as vertigo, visual field oscillation, and imbalance. In adult rodents, some Type II hair cells are regenerated and become re innervated after damage, presenting opportunities for restoring vestibular function after hair cell damage. This article reviews features of vestibular sensory cells in mammals, including their basic properties, how they develop, and how they are replaced after damage. We discuss molecules that control vestibular hair cell regeneration and highlight areas in which our understanding of development and regeneration needs to be deepened. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：96 / 105

页数：10

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