Expression and function of trk-C in favourable human neuroblastomas

被引：48

作者：

Yamashiro, DJ

Liu, XG

Lee, CP

Nakagawara, A

Ikegaki, N

McGregor, LM

Baylin, SB

Brodeur, GM

机构：

[1] Univ Penn, Childrens Hosp Philadelphia, Div Oncol, Philadelphia, PA 19104 USA

[2] Chiba Canc Ctr, Div Biochem, Chiba 260, Japan

[3] Johns Hopkins Med Inst, Ctr Oncol, Baltimore, MD 21231 USA

来源：

EUROPEAN JOURNAL OF CANCER | 1997年 / 33卷 / 12期

关键词：

neuroblastoma; trk-A; trk-B; trk-C; NT-3;

D O I：

10.1016/S0959-8049(97)00309-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Human neuroblastomas express the neurotrophin receptors trk-A and trk-B. Favourable outcome is associated with expression of trk-A, while unfavourable, MYCN amplified tumours express trk-B. In this study we examined the expression of trk-C in primary neuroblastoma tumour-derived cell lines. We found by Northern blot analysis that trk-C mRNA is expressed in 14 of 55 (25%) primary tumours. Trk-C was expressed in significantly more lower stage tumours (stage 1, 2, 4S) than higher stage tumours (stage 3, 4, P<0.04). The expression of trk-C was correlated positively with survival and negatively correlated with MYCN amplification. We also studied the function of trk-C in transfected cell lines and found that NT-3 promotes both cell survival and differentiation. Our results suggest that trk-C is involved in the biology of favourable neuroblastomas. (C) 1997 Published by Elsevier Science Ltd.

引用

页码：2054 / 2057

页数：4

共 17 条

[1] TRK AND RET PROTOONCOGENE EXPRESSION IN HUMAN NEUROBLASTOMA SPECIMENS - HIGH-FREQUENCY OF TRK EXPRESSION IN NON-ADVANCED STAGES [J].